Inhibition of type I interferon induction and signalling by mosquito-borne flaviviruses.
Inhibition of type I interferon induction and signalling by mosquito-borne flaviviruses.
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DOI：
10.1111/cmi.12737
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发表时间：
2017-05
影响因子：
3.4
通讯作者：
Donald CL
中科院分区：
文献类型：
--
作者：
Cumberworth SL;Clark JJ;Kohl A;Donald CL
黄病毒属（黄病毒科）含有许多重要的人类病原体，包括登革热和寨卡病毒，它们有可能引起严重的疾病。为了有效地在哺乳动物细胞中建立有效的感染，黄病毒已经开发出对抗宿主免疫防御的关键策略，包括 I 型干扰素反应。它们采用不同的机制来控制干扰素信号转导和效应途径，过去几十年的关键研究揭示了它们主动降低干扰素抗病毒活性的能力的新见解。鉴于许多黄病毒感染缺乏抗病毒药物或预防性治疗，充分了解这些病毒如何影响细胞过程以影响发病机制和疾病结果非常重要。这篇综述将讨论蚊媒黄病毒进化出的对抗 I 型干扰素介导的免疫反应的策略。
The Flavivirus genus (Flaviviridae family) contains a number of important human pathogens, including dengue and Zika viruses, which have the potential to cause severe disease. In order to efficiently establish a productive infection in mammalian cells, flaviviruses have developed key strategies to counteract host immune defences, including the type I interferon response. They employ different mechanisms to control interferon signal transduction and effector pathways, and key research generated over the past couple of decades has uncovered new insights into their abilities to actively decrease interferon antiviral activity. Given the lack of antivirals or prophylactic treatments for many flaviviral infections, it is important to fully understand how these viruses affect cellular processes to influence pathogenesis and disease outcome. This review will discuss the strategies mosquito‐borne flaviviruses have evolved to antagonise type I interferon mediated immune responses.