Integrating cell-signalling pathways with NF-kappaB and IKK function.
Integrating cell-signalling pathways with NF-kappaB and IKK function.
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发表时间：
2007
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通讯作者：
N. Perkins
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作者：
N. Perkins
核因子（NF）-κ B和NF-κ B激酶抑制剂（IKK）蛋白调节许多生理过程，包括先天性和适应性免疫应答、细胞死亡和炎症。NF-κ B或IKK功能的破坏有助于许多人类疾病，包括癌症。然而，NF-κ B和IKK通路并不是孤立存在的，有许多机制将它们的活性与其他细胞信号网络整合在一起。这种相互作用构成了一个决策过程，决定了NF-κ B和IKK激活的后果，并最终决定了细胞的命运。
Nuclear factor (NF)-kappaB and inhibitor of NF-kappaB kinase (IKK) proteins regulate many physiological processes, including the innate- and adaptive-immune responses, cell death and inflammation. Disruption of NF-kappaB or IKK function contributes to many human diseases, including cancer. However, the NF-kappaB and IKK pathways do not exist in isolation and there are many mechanisms that integrate their activity with other cell-signalling networks. This crosstalk constitutes a decision-making process that determines the consequences of NF-kappaB and IKK activation and, ultimately, cell fate.