A prospective study of prolonged central venous access in leukemia.
A prospective study of prolonged central venous access in leukemia.
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白血病延长中心静脉通路的前瞻性研究。
DOI：
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发表时间：
1982
期刊：
影响因子：
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通讯作者：
J. Mullen
中科院分区：
文献类型：
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作者：
J. Abrahm;J. Mullen
进行了一项为期3年的前瞻性研究，以评价右心房硅胶弹性体导管用于急性白血病成人患者的长期静脉通路。目的包括确定在血小板减少患者中插入导管的安全性和在败血症期间维持导管的可行性。在57名连续接受强化白血病治疗的患者中放置了71根导管。在3个导管插入部位发生过度出血。发生了8例导管相关感染。在36例非导管相关性和2例导管相关性细菌感染中，导管留在原位并进行了密切监测。20例患者菌血症清除。死亡14例;在8例尸检中，没有发现导管相关死亡的证据。导管使用了6，799天，包括3，932天家庭使用和2，570天粒细胞减少。数据表明血小板减少症并不妨碍导管插入，败血症粒细胞减少症患者可以安全地维持导管。
A three-year prospective study was conducted to evaluate right atrial silicone elastomer catheters for long-term venous access in adults with acute leukemia. Objectives included establishing the safety of catheter insertion in thrombocytopenic patients and the feasibility of maintaining the catheter during septicemia. Seventy-one catheters were placed in 57 consecutive patients entering intensive leukemia therapy. Excessive bleeding occurred at three catheter insertion sites. Eight catheter-related infections occurred. In 34 of 36 noncatheter-related and two catheter-related bacteremias, catheters were left in place with intensive monitoring. In 20, bacteremia cleared. Fourteen patients died; in eight autopsies, no evidence of catheter-related mortality was found. Catheters were in use 6,799 days, including 3,932 home use and 2,570 granulocytopenic days. The data indicate that thrombocytopenia does not preclude catheter insertion and that catheters can be safely maintained in septicemic granulocytopenic patients.