Effective formal synthesis of benzomalvin A
Effective formal synthesis of benzomalvin A
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DOI：
10.1007/s00706-010-0387-0
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发表时间：
2010-11-01
影响因子：
1.8
通讯作者：
Al-Said, Naim H.
中科院分区：
文献类型：
--
作者：
Al-Said, Naim H.
描述了一种从廉价的市售（S）-苯丙氨酸和靛红酸酐构建具有生物活性的化合物苯并马林霉素A的四环核心结构的短而有效的策略。该三锅法成功地实现了以54%的总收率在多克规模上合成N-去甲基苯并马林素A。
A short and effective strategy for the construction of the tetracyclic core structure of the biologically active compound benzomalvin A from cheap commercially available (S)-phenylalanine and isatoic anhydride is described. This three-pot methodology was successfully implemented to synthesize N-demethylbenzomalvin A on a multi-gram scale with 54% overall yield.