Seroprevalence of the antibody to hepatitis C in select groups in the Punjab region of Pakistan
Seroprevalence of the antibody to hepatitis C in select groups in the Punjab region of Pakistan
复制标题
DOI：
10.1097/00004836-200111000-00013
复制
发表时间：
2001-11-01
影响因子：
2.9
通讯作者：
Aslam, J
中科院分区：
文献类型：
--
作者：
Aslam, M;Aslam, J
目标：丙型肝炎在巴基斯坦的诊所呈上升趋势。为了估计该地区丙型肝炎的发生率并提高公众对该疾病的认识，在巴基斯坦的旁遮普进行了两项研究。在此之前，巴基斯坦没有做出过这样的努力。背景：在巴基斯坦旁遮普的拉合尔和古杰兰瓦拉进行了两项研究。这些研究在全市范围内进行宣传，参与者以优惠价格进行抗丙型肝炎病毒（抗HCV）阳性血清学筛查，并通过问卷进行调查。在拉合尔，有488名参与者（平均年龄。28岁，男女比例为1.4比1）。在古杰兰瓦拉，有1 922名参与者（平均年龄27岁，男女比例为1.5比1）。患者的血液进行了测试，使用免疫层析法，以确定丙型肝炎抗体使用Instatest HCV，具有非常高的灵敏度，结果：在拉合尔。抗-HCV阳性率为15.9%，古杰兰瓦拉抗-HCV阳性率为23.8%。在拉合尔，20岁及以下参与者的发生率为1.2%，20岁以上的参与者为23.5%。在古杰兰瓦拉，20岁及以下的参与者中抗-HCV阳性血清学的发生率为5.4%，20岁以上的参与者中为34%。结论：可以看出，在那些年龄小于20岁。丙型肝炎的发病率几乎与世界其他地区持平（0.5-2%）。但20岁以上的发病率很高，某些年龄段高达50%。20岁以上人群（约20 ~ 35年前）感染丙型肝炎病毒的时间范围与1964 ~ 1982年在巴基斯坦实施的天花根除计划一致。这可能表明丙型肝炎的高发病率与巴基斯坦天花疫苗的接种之间可能存在关系。
Goals: Hepatitis C is on the rise in clinics in Pakistan. To estimate the occurrence of hepatitis C in the region and to create awareness about the disease in the general public, two studies were conducted in Punjab, Pakistan. Before this, no such effort has been made in Pakistan. Background: Two studies were held in Lahore and Gujranwala of Punjab, Pakistan. These studies were advertised throughout the city, and people who participated were screened for anti-hepatitis C virus (anti-HCV)-positive serology at a concession rate and were surveyed through a questionnaire. In Lahore, there were 488 participants (mean age. 28 years-, male-to-female ratio, 1.4 to 1). In Gujranwala, there were 1,922 participants (mean age, 27 years: male-to-female ratio, 1.5 to 1). The patients' blood was tested using an immuno-chromatography to identify the antibody to hepatitis C using Instatest HCV, with very high sensitivity, Results: In Lahore. the occurrence of anti-HCV-positive serology was 15.9%, In Gujranwala, the occurrence of anti-HCV-positive serology was 23.8%. In Lahore, the occurrence was 1.2% in participants 20 years of age and younger and was 23.5% in those who were more than 20 years of age. In Gujranwala, the occurrence of anti-HCV-positive serology was 5.4% in participants 20 years of age and younger and was 34% in those who were more than 20 years of age. Conclusion: It can be seen that in those younger than 20 years of age. the occurrence of hepatitis C is almost at par with the rest of the world (0.5-2%). However, those more than 20 years of age had a very high occurrence, as high as 50% in certain age groups. The time-frame of contraction of the HCV for those individuals more than 20 years of age (approximately 20 to 35 years ago) corresponds with that of the smallpox eradication program conducted in Pakistan from 1964 to 1982. This may indicate the likelihood of a relationship between the high rate of hepatitis C and the administration of the smallpox vaccine in Pakistan.