A seroepidemiological study of the risks of Q fever infection in Japanese veterinarians
A seroepidemiological study of the risks of Q fever infection in Japanese veterinarians
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DOI：
10.1023/a:1020018907452
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发表时间：
2001-01-01
影响因子：
13.6
通讯作者：
Hirai, K
中科院分区：
文献类型：
--
作者：
Abe, T;Yamaki, K;Hirai, K
Q热是一种广泛传播的人畜共患病，其病原体是伯氏柯克斯体。虽然世界各国都有Q热病例的记录，但这种疾病在日本的流行情况尚不清楚。Q热对受雇于动物学专业的人来说是一种已证实的职业危害，但对日本兽医的风险尚未量化。为了评估日本兽医的风险，我们对267名兽医的血清样本进行了血清学调查。由352名医务人员和2003名健康献血者组成的两个对照组也被评估。以伯氏梭菌Nine Mile株为抗原，采用间接免疫荧光法(IFA)检测血清抗体效价。兽医免疫球蛋白抗体阳性率为13.5%，高于献血员(3.6%，P<0.001)和医务人员(5.1%，P<0.001)。这些发现表明，与其他日本人相比，日本兽医感染伯氏梭菌的风险更高。这项研究的一个有趣的发现是，献血者组的IgG和IgM抗体阳性率在年轻个体中更高。IgM抗体阳性率以30岁以下女性最高。
The causative agent of Q fever, a widespread zoonotic disease, is the bacteria Coxiella burnetii. Although cases of Q fever have been documented in countries throughout the world, the prevalence of the disease in Japan is not yet known. Q fever is a demonstrated occupational hazard to those employed in zoological professions, but the risk to Japanese veterinarians has not yet been quantified. In order to evaluate the risk to Japanese veterinarians, we performed a serological survey using serum samples from 267 veterinarians. Two control groups consisting of 352 medical workers and 2003 healthy blood donors were also evaluated. The antibody titers of the serum samples were measured by indirect immunofluorescence assay (IFA) using phase II C. burnetii Nine Mile strain as the antigen. The positive rate of IgG antibody was 13.5% in the veterinarians, which was higher than in the blood donors (3.6%, p < 0.001) and medical workers (5.1%, p < 0.001). These findings suggest that Japanese veterinarians have a higher risk of infection by C. burnetii than other members of the Japanese population. An interesting finding of this study was that positive rates of IgG and IgM antibodies in the blood donor group were higher in younger individuals. The IgM antibody positive rate was the highest in females under 30 years old.