PROCESSING OF PROSOMATOSTATIN
PROCESSING OF PROSOMATOSTATIN
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DOI：
10.1016/0026-0495(90)90202-n
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发表时间：
1990-09-01
影响因子：
9.8
通讯作者：
MUFSON, EJ
中科院分区：
文献类型：
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作者：
BENOIT, R;ESCH, F;MUFSON, EJ
除了生长抑素-14（SS-14）和生长抑素-28（SS-28）之外，还从生长抑素原（proSS）产生几种肽。这些是SS-28（1-12），proSS（1-76），以及最近显示的proSS（1-63）和antrin。这些分子形式的比例在不同组织和不同物种之间存在重要差异。在人脑中对前体的加工产生最少量的SS-28（1-12）和高水平的proSS（1-76），即在皮质区和终纹的床核中。这与大鼠脑中的发现相反，其中SS-28（1-12）是主要的分子形式。对应于proSS（1-10）的Antrin在胃的胃窦部分达到其最高浓度（117 ± 13 pmol/g湿重），在此处发现其存在于δ细胞的分泌颗粒中。我们观察到在各种组织提取物的层析后，antrin和proSS（1-63）的水平之间呈反比关系。这表明这两种肽之间存在同源物-产物关系。
Several peptides are generated from prosomatostatin (proSS) in addition to somatostatin-14 (SS-14) and somatostatin-28 (SS-28). These are SS-28(1–12), proSS(1–76) and, as shown more recently, proSS(1–63) and antrin. Important variations in the proportion of these molecular forms are seen among different tissues and among different species. Processing of the precursor in the human brain yields minimal quantities of SS-28(1–12) and high levels of proSS(1–76), namely in cortical areas and in the bed nucleus of the stria terminalis. This is in contrast with findings in rat brain, where SS-28(1–12) is a predominant molecular form. Antrin, which corresponds to proSS(1–10), reaches its highest concentration in the antral portion of the stomach (117 ± 13 pmol/g wet weight), where it is found in secretory granules of delta cells. We observed an inverse relationship between levels of antrin and proSS(1–63) after chromatography of various tissue extracts. This suggests a precursor-product relationship between these two peptides.