Non-Invasive Characterization of the Organic Coating of Biocompatible Quantum Dots Using Nuclear Magnetic Resonance Spectroscopy
Non-Invasive Characterization of the Organic Coating of Biocompatible Quantum Dots Using Nuclear Magnetic Resonance Spectroscopy
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DOI：
10.1021/acs.chemmater.8b01033
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发表时间：
2018-04
影响因子：
8.6
通讯作者：
Chengqi Zhang;G. Palui;Birong Zeng;Naiqian Zhan;Banghao Chen;H. Mattoussi
中科院分区：
文献类型：
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作者：
Chengqi Zhang;G. Palui;Birong Zeng;Naiqian Zhan;Banghao Chen;H. Mattoussi
胶体量子点由半导体核和表面包覆有机壳层组成，在光谱学、电荷和能量转移相互作用、器件设计以及生物学中作为探针等领域引起了广泛的兴趣。尽管这些材料的生长取得了显著进展，但关于有机涂层的分子排列的信息相当有限。在这里，几种核磁共振（NMR）光谱技术已被组合来表征生物相容性的CdSe-ZnS量子点（QD）的表面配体结构（S）。这些材料已通过光诱导配体交换方法制备，其中天然疏水涂层被取代，原位，与一系列的聚乙二醇改性的硫辛酸为基础的配体。我们首先结合了扩散有序光谱与异质单量子相干测量，概述了检测到的质子信号仅来自表面结合配体的条件。
Colloidal quantum dots, made of semiconductor cores and surface coated with an organic shell, have generated much interest in areas ranging from spectroscopy to charge and energy transfer interactions to device design, and as probes in biology. Despite the remarkable progress in the growth of these materials, rather limited information about the molecular arrangements of the organic coating is available. Here, several nuclear magnetic resonance (NMR) spectroscopic techniques have been combined to characterize the surface ligand structure(s) on biocompatible CdSe-ZnS quantum dots (QDs). These materials have been prepared via a photoinduced ligand exchange method in which the native hydrophobic coating is substituted, in situ, with a series of polyethylene glycol-modified lipoic acid-based ligands. We first combined diffusion ordered spectroscopy with heteronuclear single-quantum coherence measurements to outline the conditions under which the detected proton signals emanate from only surface-bound ligands ...