Immune responsiveness in a rat model for type II diabetes (Zucker rat, fa/fa): Susceptibility to Candida albicans infection and leucocyte function
Immune responsiveness in a rat model for type II diabetes (Zucker rat, fa/fa): Susceptibility to Candida albicans infection and leucocyte function
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DOI：
10.1099/00222615-44-4-277
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发表时间：
1996-04-01
影响因子：
3
通讯作者：
Casteel, N
中科院分区：
文献类型：
--
作者：
Plotkin, BJ;Paulson, D;Casteel, N
肥胖相关糖尿病与感染风险增加之间存在因果关系，非胰岛素依赖型糖尿病(NIDDM)的模型肥胖(FA/FA)Zucker大鼠清除循环和组织中白色念珠菌的能力与瘦(Fa/Fa，Fa/Fa)Zucker大鼠对照的能力进行比较作为免疫功能的衡量标准，在瘦Zucker大鼠中建立组织定植所需的ID50是静脉注射后9天肥胖Zucker大鼠的1.18对数(10)倍。通过注射酵母菌悬浮液，肥胖大鼠的器官的酵母/克器官负荷是瘦大鼠的10倍，肾脏被确定为定植的主要目标器官，肥胖大鼠血清中白色念珠菌形成生殖管的速度是瘦大鼠血清中的1.5倍，瘦Zucker大鼠的腹膜多形核白细胞、常驻巨噬细胞和硫代乙酸酯诱导的巨噬细胞对摄入的酵母细胞的杀灭能力明显高于肥胖Zucker大鼠的类似细胞群。
There is a causal relationship between obesity-associated diabetes and an increased risk of infection, The ability of obese (fa/fa) Zucker rats, a model for non-insulin-dependent diabetes mellitus (NIDDM), to clear Candida albicans from the circulation and tissues was compared to that of lean (Fa/fa, Fa/Fa) Zucker rat controls as a measure of immune function, The ID50 necessary to establish tissue colonisation in lean Zucker rats was 1.18 log(10) times greater than that determined for the obese Zucker rats, Nine days after intravenous (i.v.) injection of a yeast suspension, the organs of obese rats had a 10-fold greater yeast/g organ burden than did lean rats, The kidney was determined to be the primary target organ for colonisation, Germ-tube formation by C. albicans occurred at a rate 1.5 times faster in serum from obese rats than in serum from lean rats, Peritoneal polymorphonuclear leucocytes, resident macrophages and thioglycollate-elicited macrophages from lean Zucker rats displayed a significantly higher ability to kill ingested yeast cells than analogous cell populations from obese Zucker rats.