Effect of Chlorogenic Acids on Cognitive Function in Mild Cognitive Impairment: A Randomized Controlled Crossover Trial
Effect of Chlorogenic Acids on Cognitive Function in Mild Cognitive Impairment: A Randomized Controlled Crossover Trial
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DOI：
10.3233/jad-190757
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发表时间：
2019-01-01
影响因子：
4
通讯作者：
Asada, Takashi
中科院分区：
文献类型：
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作者：
Ochiai, Ryuji;Saitou, Katsuyoshi;Asada, Takashi
背景：轻度认知障碍（MCI）是一个全球范围的问题，很大程度上是由于老年人口的快速增长。咖啡豆中含有的主要多酚——绿原酸（CGA），可以提高健康人的注意力。然而，CGA 治疗 MCI 的效用尚未得到评估。 目的：确定连续摄入 CGA 对诊断为 MCI 的患者认知功能（尤其是注意力）的影响。方法：该研究是一项随机对照交叉试验，包括 34 名 MCI 患者。参与者被随机分为两组：首先摄入安慰剂饮料的组和首先摄入含有 CGA（553.6 毫克/瓶）的活性饮料的组，每天两次，持续 12 周。经过 4 周的清除期后，受试者以相同的方式摄入另一种饮料（即安慰剂或活性饮料）。终点指标包括日本版简易精神状态检查 (MMSE)、日本版阿尔茨海默病评估量表认知成分 (ADAS-cog) 测试整体认知功能、日本版跟踪测试 (TMT-A、TMT-B) 测试注意力，以及评估安全性的血液测试结果。 结果：在 TMT-B 测试中，与饮用 CGA 饮料相比，参与者在饮用 CGA 饮料时的错误数量显着减少。安慰剂饮料（p < 0.05），尽管测试完成时间没有差异。 MMSE、ADAS-cog 和 TMT-A 的得分在不同条件下没有显着差异。结论：持续摄入 CGA 似乎可以改善 MCI 认知功能中的注意力和执行功能。
Background: Mild cognitive impairment (MCI) is a global-scale issue, due in large part to the rapidly growing elderly population. The main polyphenol contained in coffee beans, chlorogenic acid (CGA), improves attention in healthy individuals. The utility of CGAs for treating MCI, however, has not been evaluated.Objective: To determine the effects of continuous CGA intake on cognitive function, especially attention, in patients diagnosed with MCI.Methods: The study was a randomized controlled crossover trial including 34 patients with MCI. Participants were randomly divided into two groups: Those who first ingested a placebo beverage and those who first ingested an active beverage containing CGAs (553.6 mg/bottle) twice daily for 12 weeks. After a 4-week washout period, the subjects ingested the other beverage (i.e., placebo or active beverage) in the same manner. Endpoint measures included scores on the Japanese version of the Mini-Mental State Examination (MMSE), the Japanese version of the Alzheimer's Disease Assessment Scale-cognitive component (ADAS-cog) testing overall cognitive function, and the Japanese version of the Trail Making Test (TMT-A, TMT-B) testing attention, along with the results of blood tests to evaluate safety.Results: In the TMT-B test, participants had a significantly reduced number of errors while ingesting the CGA beverage as compared with the placebo beverage (p < 0.05), although there was no difference in test completion time. Scores in the MMSE, ADAS-cog, and TMT-A did not differ significantly between conditions.Conclusion: Continuous intake of CGAs appears to improve attention and executive function among cognitive functions in MCI.