Smaller regional gray matter volume in homeless african american cocaine-dependent men: a preliminary report.
Smaller regional gray matter volume in homeless african american cocaine-dependent men: a preliminary report.
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DOI：
10.2174/1874440001105010057
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Ding Z
中科院分区：
文献类型：
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作者：
Weller RE;Stoeckel LE;Milby JB;Bolding M;Twieg DB;Knowlton RC;Avison MJ;Ding Z
成瘾的模型包括大脑执行功能/抑制控制部分的异常。虽然以前的研究报告了可卡因依赖者结构异常的证据，但没有一个是专门针对无家可归者的。目前的初步研究调查了这样一个未被充分研究的群体——无家可归的、依赖快克可卡因的非洲裔美国人（n = 9）的大脑结构，并将其与健康对照组（n = 8）进行了比较。使用基于体素的形态测量（VBM）和感兴趣区域（ROI）分析结构数据。无家可归的可卡因依赖者在背外侧前额皮质、前扣带、小脑、脑岛和颞上回的灰质体积较小。这些区域大多是执行功能或抑制性控制的附属。这些结果与之前大多数对非无家可归的可卡因依赖者的研究结果相似。可卡因依赖个体大脑执行功能/抑制控制区灰质减少可能是成瘾发展和/或药物滥用后果的预先存在的风险因素。
Models of addiction include abnormalities in parts of the brain involving executive function/inhibitory control. Although previous studies have reported evidence of structural abnormalities in cocaine-dependent individuals, none have specifically targeted the homeless. The present preliminary study investigated brain structure in such an understudied group, homeless, crack-cocaine-dependent African American men (n = 9), comparing it to that in healthy controls (n = 8). Structural data were analyzed using voxel based morphometry (VBM) and a regions of interest (ROI) analysis. Homeless cocaine-dependent individuals had smaller gray matter volume in dorsolateral prefrontal cortex, anterior cingulate, the cerebellum, insula, and superior temporal gyrus. Most of these areas subserve executive function or inhibitory control. These results are similar to those found in most previous studies of non-homeless cocaine-dependent individuals. Reduced gray matter in executive function/inhibitory control regions of the brain in cocaine-dependent individuals may be a preexisting risk factor for the development of addiction and/or a consequence of drug abuse.