Association study of COMT gene Val158Met polymorphism with auditory P300 and performance on neurocognitive tests in patients with schizophrenia and their relatives
Association study of COMT gene Val158Met polymorphism with auditory P300 and performance on neurocognitive tests in patients with schizophrenia and their relatives
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DOI：
10.1080/15622970600670970
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发表时间：
2006-01-01
影响因子：
3.1
通讯作者：
Ebstein, Richard
中科院分区：
文献类型：
--
作者：
Golimbet, Vera;Gritsenko, Inga;Ebstein, Richard
许多研究报道了儿茶酚-O-甲基转移酶（COMT）基因Val 158 Met多态性与精神分裂症患者及其亲属和健康对照的神经心理学特征之间的关联，Met等位基因携带者在神经认知任务中的表现优于瓦尔等位基因携带者。但这种关联并没有在所有研究中得到证实。本研究旨在进一步探讨COMT基因与工作记忆和言语记忆等神经认知特征的关系，以及与P300事件相关电位（听觉oddball）的关系。共319人的样本，包括精神分裂症患者，他们的亲属和控制，进行了研究。Vall 58 Met基因型在神经认知任务中的表现没有显著差异。Met/Met基因型与亲属中央顶叶区的高振幅之间存在关联。可以解释的COMT基因多态性和神经认知性状的先前研究的非复制的因素进行了讨论。我们认为：（1）Val 158 Met多态性对一般脑激活的影响大于对特定神经认知测试的直接影响;（2）P300振幅似乎与这种激活相关，沿着信息加工，反映了受试者的情感和人格特征。
A number of studies have reported an association between catechol-O-methyltransferase (COMT) gene Val158Met polymorphism and neuropsychological traits in patients with schizophrenia, their relatives and healthy controls, with the Met allele carriers performing better on neurocognitive tasks than those with the Val allele. But the association was not confirmed in all studies. The present paper was aimed at further investigation of the COMT gene relationship with some neurocognitive traits, assessing mainly working and verbal memory, and to P300 event-related potentials (auditory oddball). A total sample of 319 individuals, including schizophrenic patients, their relatives and controls, was studied. No significant differences in performance of neurocognitive tasks were found by Vall58Met genotypes. An association was observed between the Met/Met genotype and higher amplitude in centro-parietal area in relatives. Factors that could explain the non-replication of previous studies on the COMT gene polymorphism and neurocognitive traits are discussed. We suggest here that (1) Val158Met polymorphisin rather exerts a modifying influence on brain activation in general than impacts directly on performance of the particular neurocognitive test, and (2) P300 amplitude seems to be a correlate of this activation reflecting, along with information processing, the subject's affective and personality features.