Dendritic calcium conductances generate high-frequency oscillation in thalamocortical neurons
Dendritic calcium conductances generate high-frequency oscillation in thalamocortical neurons
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DOI：
10.1073/pnas.94.2.724
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发表时间：
1997-01-21
影响因子：
11.1
通讯作者：
Llinas, R
中科院分区：
文献类型：
--
作者：
Pedroarena, C;Llinas, R
在豚鼠脑切片中，皮质投射丘脑神经元在其胞体去极化超过-45 mV时显示高频膜电位振荡（20-80 Hz）。这些振荡，优先位于树突部位，由P/Q型钙通道的激活支持，而不是预期的持续钠电导，负责其他中枢神经元中的这种节律行为。短超极化脉冲重置相位并瞬时增加这些振荡的振幅，这种固有的丘脑电反应性可能作为一种基于细胞的时间结合机制，使皮层反馈突触输入的时间一致性变得尖锐，已知分布在丘脑神经元的远端树突部位。
Cortical-projecting thalamic neurons, in guinea pig brain slices, display high-frequency membrane potential oscillations (20-80 Hz), when their somata are depolarized beyond -45 mV. These oscillations, preferentially located at dendritic sites, are supported by the activation of P/Q type calcium channels, as opposed to the expected persistent sodium conductance responsible for such rhythmic behavior in other central neurons, Short hyperpolarizing pulses reset the phase and transiently increase the amplitude of these oscillations, This intrinsic thalamic electroresponsiveness may serve as a cellular-based temporal binding mechanism that sharpens the temporal coincidence of cortical-feedback synaptic inputs, known to distribute at remote dendritic sites on thalamic neurons.