Sulphate polyanions prolong the incubation period of scrapie-infected hamsters.
Sulphate polyanions prolong the incubation period of scrapie-infected hamsters.
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硫酸盐聚阴离子可延长感染痒病的仓鼠的潜伏期。
DOI：
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发表时间：
1992
影响因子：
3.8
通讯作者：
M. Pocchiari
中科院分区：
文献类型：
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作者：
A. Ladogana;P. Casaccia;L. Ingrosso;M. Cibati;M. Salvatore;Y. Xi;C. Masullo;M. Pocchiari
通过腹腔或脑内途径，研究了有机硫酸盐多阴离子——硫酸戊聚糖（SP54）、硫酸葡聚糖500 （DS500）和苏拉明对感染了263K型痒病的金色叙利亚仓鼠的影响。在接种后2 h内给药，SP54对延长疾病潜伏期的效果最大。在瘙痒病接种24 h后给予相同剂量的SP54，在一些动物中有明显的效果，而在另一些动物中没有效果。这一结果表明，SP54抑制瘙痒剂进入接种部位（即腹膜）的神经末叶和/或载体细胞的摄取，并且这一事件发生在约24小时内。当在瘙痒剂注射后2小时内通过腹腔注射给药时，DS500与SP54（54.4天）具有相似的作用（潜伏期延迟22.4天），但效果不如SP54（潜伏期延迟22.4天），苏拉明只有最小的作用（10天）。这项研究表明，治疗动物和人的痒病和相关海绵状脑病是可能的，只有在药物到达临床靶脑区域之前。
The effect of the organic sulphated polyanions, pentosan sulphate (SP54), dextran sulphate 500 (DS500) and suramin, have been tested on golden Syrian hamsters infected with the 263K strain of scrapie by the intraperitoneal (i.p.) or the intracerebral route. SP54 had the greatest effect in prolonging the incubation period of the disease when administered within 2 h of the i.p. inoculum. The same amount of SP54 given 24 h after scrapie inoculation had a potent effect in some animals and no effect in others. This result suggests that SP54 inhibits the uptake of the scrapie agent into the nerve endings and/or carrier cells at the site of the inoculum, i.e. the peritoneum, and that this event occurs in about 24 h. DS500 had a similar although less potent effect (22.4 days delay during the incubation period) than SP54 (54.4 days) when administered within 2 h of scrapie injection by the i.p. route, and suramin had only a minimal effect (10 days). This study suggests that treatment of scrapie and related spongiform encephalopathies of animals and man is possible only before the agent has reached the clinical target areas of the brain.