Glycated Serum Protein Genetics and Pleiotropy with Cardiometabolic Risk Factors
Glycated Serum Protein Genetics and Pleiotropy with Cardiometabolic Risk Factors
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DOI：
10.1155/2019/2310235
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发表时间：
2019-01-01
影响因子：
4.3
通讯作者：
Williams-Blangero, Sarah
中科院分区：
文献类型：
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作者：
Johnson, Matthew P.;Keyho, Ryan;Williams-Blangero, Sarah
空腹血糖（FG）或糖化血红蛋白A1 c（HbA 1c）的测量是两种临床批准的方法，通常用于确定糖尿病，这两者都受到遗传因素的影响。然而，获得FG或HbA 1c的准确测量值并非没有挑战。测量糖化血清蛋白（GSP）提供了一种评估糖化血清蛋白的替代方法。本研究的目的是估计遗传力的GSP和GSP表示为总血清白蛋白（%GA）的百分比，使用方差分量的方法和本地化的基因组区域（QTL），港口基因可能会影响GSP和%GA性状变异的一个大的扩展多代系谱从尼泊尔吉里（n=1,800）。我们还进行了定量双变量分析，以评估GSP或%GA和几个心脏代谢性状之间的关系。加性遗传效应显著影响GSP和%GA水平的变化（p值分别为1.15 × 10（-5）和3.39 × 10（-5））。我们在染色体11 q上定位了一个显著的（LOD评分=3.18）和新的GSP QTL，该QTL先前已与2型糖尿病相关。11号染色体QTL内的两个常见（MAF>0.4）SNP与GSP相关（调整后的p值
Measurements of fasting glucose (FG) or glycated hemoglobin A1c (HbA1c) are two clinically approved approaches commonly used to determine glycemia, both of which are influenced by genetic factors. Obtaining accurate measurements of FG or HbA1c is not without its challenges, though. Measuring glycated serum protein (GSP) offers an alternative approach for assessing glycemia. The aim of this study was to estimate the heritability of GSP and GSP expressed as a percentage of total serum albumin (%GA) using a variance component approach and localize genomic regions (QTLs) that harbor genes likely to influence GSP and %GA trait variation in a large extended multigenerational pedigree from Jiri, Nepal (n=1,800). We also performed quantitative bivariate analyses to assess the relationship between GSP or %GA and several cardiometabolic traits. Additive genetic effects significantly influence variation in GSP and %GA levels (p values: 1.15x10(-5) and 3.39x10(-5), respectively). We localized a significant (LOD score=3.18) and novel GSP QTL on chromosome 11q, which has been previously linked to type 2 diabetes. Two common (MAF>0.4) SNPs within the chromosome 11 QTL were associated with GSP (adjusted pvalue