The NIH Extracellular RNA Communication Consortium.
The NIH Extracellular RNA Communication Consortium.
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DOI：
10.3402/jev.v4.27493
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发表时间：
2015
影响因子：
16
通讯作者：
Venkatachalam S
中科院分区：
文献类型：
--
作者：
Ainsztein AM;Brooks PJ;Dugan VG;Ganguly A;Guo M;Howcroft TK;Kelley CA;Kuo LS;Labosky PA;Lenzi R;McKie GA;Mohla S;Procaccini D;Reilly M;Satterlee JS;Srinivas PR;Church ES;Sutherland M;Tagle DA;Tucker JM;Venkatachalam S
细胞外RNA(ExRNA)通讯联盟是由美国国立卫生研究院共同基金资助的一项倡议，代表了一个由研究人员组成的联盟，以解决exRNA研究领域的关键问题。首要目标是生成一个多组成部分的社区资源，用于共享基本的科学发现、协议以及创新的工具和技术。主要举措包括：(A)生成有助于疾病诊断和治疗的正常健康人体液中存在的exRNA的参考目录；(B)定义exRNA生物发生、分布、摄取和功能的基本原理，以及开发分子工具、技术和成像方式以使这些研究成为可能；(C)确定疾病的exRNA生物标志物；(D)展示作为治疗剂的exRNA的临床用途，并开发这些研究所需的可扩展技术；以及(E)开发社区资源，即exRNA图谱，为科学界提供获取exRNA数据的途径，标准化的exRNA方案，以及由受资助的调查人员产生的其他有用的工具和技术。
The Extracellular RNA (exRNA) Communication Consortium, funded as an initiative of the NIH Common Fund, represents a consortium of investigators assembled to address the critical issues in the exRNA research arena. The overarching goal is to generate a multi-component community resource for sharing fundamental scientific discoveries, protocols, and innovative tools and technologies. The key initiatives include (a) generating a reference catalogue of exRNAs present in body fluids of normal healthy individuals that would facilitate disease diagnosis and therapies, (b) defining the fundamental principles of exRNA biogenesis, distribution, uptake, and function, as well as development of molecular tools, technologies, and imaging modalities to enable these studies, (c) identifying exRNA biomarkers of disease, (d) demonstrating clinical utility of exRNAs as therapeutic agents and developing scalable technologies required for these studies, and (e) developing a community resource, the exRNA Atlas, to provide the scientific community access to exRNA data, standardized exRNA protocols, and other useful tools and technologies generated by funded investigators.