Association Between Apolipoprotein B XbaI Polymorphism and Coronary Heart Disease in Han Chinese Population: A Meta-Analysis
Association Between Apolipoprotein B XbaI Polymorphism and Coronary Heart Disease in Han Chinese Population: A Meta-Analysis
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DOI：
10.1089/gtmb.2015.0126
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发表时间：
2016-06-01
影响因子：
1.4
通讯作者：
Rao, Shaoqi
中科院分区：
文献类型：
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作者：
Chen, Yeda;Lin, Meihua;Rao, Shaoqi
目的：通过系统分析多项独立研究，探讨中国汉族人群载脂蛋白B（ApoB）XbaI多态性（rs693）与冠心病（CHD）风险的关系。方法：对所选文献进行Hardy-Weinberg平衡检验，分析基因型间的遗传平衡。研究质量采用NewcastleOttawa量表进行评估。使用Power and Precision V4软件进行功效分析。基于异质性，使用固定或随机效应模型。用Begg漏斗图检验和Egger线性回归检验对发表偏倚进行量化和检验。采用Stata 12.0软件进行Meta分析。结果如下：本荟萃分析共纳入10项符合条件的关联研究，合并样本包括1195例CHD患者和1178例健康对照。通过使用上述两种方法，未获得关于纳入研究的发表偏倚的一致推断。X-与X+等位基因和X+X+ + X+X-与X-X-基因型的合并优势比（95%置信区间[CI]）分别为2.25（1.40-3.62）和2.21（1.39-3.50）。结论：这项荟萃分析表明，ApoB XbaI等位基因对中国汉族人群患CHD的风险很大。
Objective: To examine the association between apolipoprotein B (ApoB) XbaI polymorphisms (rs693) and coronary heart disease (CHD) risk among the Han Chinese population by systematically analyzing multiple independent studies. Methods: The Hardy-Weinberg equilibrium test was applied to check genetic equilibrium among genotypes for the selected literatures. The quality of the studies was assessed by using the NewcastleOttawa Scale. Power analysis was performed with Power and Precision V4 software. A fixed or random effect model was used on the basis of heterogeneity. Publication bias was quantified and examined with Begg's funnel plot test and Egger's linear regression test. The meta-analysis was performed by Stata 12.0 software. Results: A total of 10 eligible association studies were included in this meta-analysis, and the pooled sample consisted of 1195 CHD patients and 1178 health controls. No consistent inference regarding publication bias for the included studies was obtained by using the two above-mentioned methods. The pooled odds ratios (95% confidence intervals [CIs]) for X- versus X+ allele and X+X+ + X+X- versus X-X- genotype were 2.25 (1.40-3.62) and 2.21 (1.39-3.50), respectively. Conclusions: This meta-analysis indicated that ApoB XbaI allele confers a significant risk towards the development of CHD among the Han Chinese population.