Oxidized LDL immune complexes stimulate collagen IV production in mesangial cells via Fc gamma receptors I and III.
Oxidized LDL immune complexes stimulate collagen IV production in mesangial cells via Fc gamma receptors I and III.
复制标题
DOI：
10.1016/j.clim.2011.01.016
复制
发表时间：
2011-06
期刊：
影响因子：
--
通讯作者：
Lopes-Virella MF
中科院分区：
文献类型：
--
作者：
Abdelsamie SA;Li Y;Huang Y;Lee MH;Klein RL;Virella G;Lopes-Virella MF
Diabetic nephropathy is characterized by progressive mesangial expansion. Although we have reported that circulating oxidized LDL-containing immune complexes (oxLDL-ICs) are associated with abnormal levels of albuminuria, the underlying mechanisms have not been investigated. In this study, we have studied the effect of oxLDL-ICs on collagen IV expression by mesangial cells. We found that oxLDL-ICs markedly stimulated collagen IV expression in a concentration- and time-dependent fashion while oxLDL only had moderate effect. We also found that oxLDL-ICs stimulated collagen IV expression by engaging Fc gamma receptor (FcγR) I and III, but not FcγRII, and that p38 MAPK, JNK and PKC pathways were involved in collagen IV expression. Furthermore, we found that oxLDL-ICs stimulated FcγRI expression, suggesting a positive feedback mechanism involved in oxLDL-IC-stimulated collagen IV expression. Taken together, this study showed that oxLDL-ICs stimulated collagen IV in mesangial cells via FcγRI and FcγRIII, and the expression of FcγRI was increased by oxLDL-ICs.
登录
查看更多内容
影响因子：
19.6
作者：
KASHGARIAN, M;STERZEL, RB
通讯作者：
STERZEL, RB
影响因子：
5.1
作者：
Lee, HS
通讯作者：
Lee, HS
影响因子：
8.7
作者：
Mironova, M;Virella, G;LopesVirella, MF
通讯作者：
LopesVirella, MF
影响因子：
15.9
作者：
NEUWIRTH, R;SINGHAL, P;SCHLONDORFF, D
通讯作者：
SCHLONDORFF, D
影响因子：
8.2
作者：
Atchley, DH;Lopes-Virella, MF;Virella, G
通讯作者：
Virella, G