Salivary adenoid cystic carcinoma in Denmark 1990-2005: Outcome and independent prognostic factors including the benefit of radiotherapy. Results of the Danish Head and Neck Cancer Group (DAHANCA)
Salivary adenoid cystic carcinoma in Denmark 1990-2005: Outcome and independent prognostic factors including the benefit of radiotherapy. Results of the Danish Head and Neck Cancer Group (DAHANCA)
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DOI：
10.1016/j.oraloncology.2015.10.002
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发表时间：
2015-12-01
期刊：
影响因子：
4.8
通讯作者：
Godballe, Christian
中科院分区：
文献类型：
--
作者：
Bjorndal, Kristine;Krogdahl, Annelise;Godballe, Christian
目的：描述的结果和预后因素，包括放射治疗的效果，在一个连续的国家系列的涎腺腺样囊性cancer.Methods：从丹麦国家涎腺癌数据库的DAHANCA结构，201例诊断为腺样囊性癌，并治疗的治疗意图，确定在1990年至2005年期间。结果：10年粗生存率和疾病特异性生存率分别为58%和75%。10年局部区域控制率为70%，36%的患者在随访期间复发（中位数为7.5年）; 18%发生远处转移（最常见于肺部）。在多因素分析中，分期和切缘状态都是生存和局部控制的重要因素。放疗并没有提高生存率，但它确实提高了locoregional控制rate.Conclusions：治疗的选择是手术，尽可能广泛的利润，包括选择性，选择性颈淋巴结清扫术。对于肿瘤切除不完全、疾病分期较高和肿瘤呈实体生长模式的患者，应考虑辅助放疗。(C)2015爱思唯尔有限公司版权所有。
Aim: To describe outcome and prognostic factors, including the effect of radiotherapy, in a consecutive national series of salivary gland adenoid cystic carcinomas.Methods: From the national Danish salivary gland carcinoma database in the structure of DAHANCA, 201 patients diagnosed with adenoid cystic carcinoma, and treated with a curative intent, were identified in the period between 1990 and 2005. Variables necessary for statistical analyses were extracted from the database.Results: The 10-year crude survival and disease specific survival rates were 58% and 75%, respectively. The 10-year locoregional control rate was 70%, and 36% of patients experienced a recurrence during follow-up (median 7.5 years); 18% developed distant metastases (most commonly to the lungs). In multivariate analysis, stage and margin status were both important factors with regards to survival and locoregional control. Radiotherapy did not improve survival, but it did improve the locoregional control rate.Conclusions: The treatment of choice is surgery with as wide margins as possible including elective, selective neck dissection. Adjuvant radiotherapy should be considered in patients with incomplete tumor resection, high disease stages, and tumors with a solid growth pattern. (C) 2015 Elsevier Ltd. All rights reserved.