Antibiotic resistance in Chlamydiae.
Antibiotic resistance in Chlamydiae.
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DOI：
10.2217/fmb.10.96
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发表时间：
2010-09
影响因子：
3.1
通讯作者：
Rockey DD
中科院分区：
文献类型：
--
作者：
Sandoz KM;Rockey DD
关于衣原体的抗生素耐药性的报道很少，也没有从人类收集的菌株中天然和稳定的抗生素耐药性的例子。虽然有几份临床分离株对抗生素表现出耐药性的报告，但这些菌株要么在体外失去了耐药性表型，要么完全失去了活力。实验室衣原体培养程序的差异、临床分离株的低回收率以及培养中观察到的异型耐药性的未知意义可能会干扰抗生素耐药性的识别和解释。虽然对人类致病的衣原体中尚未出现抗生素耐药性，但几条证据表明它们能够表达显著的耐药表型。衣原体在体外进化成抗生素耐药性的熟练能力被当代诱变、重组和遗传转化的例子所证明。从猪中分离出的四环素耐药猪衣原体菌株也强调了它们在受到显著的选择压力时获得抗生素耐药基因的适应能力。
There are few documented reports of antibiotic resistance in Chlamydia and no examples of natural and stable antibiotic resistance in strains collected from humans. While there are several reports of clinical isolates exhibiting resistance to antibiotics, these strains either lost their resistance phenotype in vitro, or lost viability altogether. Differences in procedures for chlamydial culture in the laboratory, low recovery rates of clinical isolates and the unknown significance of heterotypic resistance observed in culture may interfere with the recognition and interpretation of antibiotic resistance. Although antibiotic resistance has not emerged in chlamydiae pathogenic to humans, several lines of evidence suggest they are capable of expressing significant resistant phenotypes. The adept ability of chlamydiae to evolve to antibiotic resistance in vitro is demonstrated by contemporary examples of mutagenesis, recombination and genetic transformation. The isolation of tetracycline-resistant Chlamydia suis strains from pigs also emphasizes their adaptive ability to acquire antibiotic resistance genes when exposed to significant selective pressure.