The effects of β3-adrenoceptor agonist CL-316,243 on adiponectin, adiponectin receptors and tumor necrosis factor-α expressions in adipose tissues of obese diabetic KKAy mice
The effects of β3-adrenoceptor agonist CL-316,243 on adiponectin, adiponectin receptors and tumor necrosis factor-α expressions in adipose tissues of obese diabetic KKAy mice
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DOI：
10.1016/j.ejphar.2008.01.028
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发表时间：
2008-04-14
影响因子：
5
通讯作者：
Kawakami, Yasushi
中科院分区：
文献类型：
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作者：
Fu, Ling;Isobe, Kazumasa;Kawakami, Yasushi
我们研究了β（3）-肾上腺素受体激动剂5-[（2 R）-2-[[（2 R）-2-（3-氯苯基）-2-羟乙基]氨基]丙基]-1，3-苯并间二氧杂环戊烯-2，2-二羧酸酯（CL-316，243）对肥胖糖尿病KKAy小鼠的影响。CL-316，243皮下给药2周可降低血糖、胰岛素、甘油三酯、游离脂肪酸和肿瘤坏死因子-α（TNF-α）的血清水平，并增加脂联素。KKAy小鼠附睾白色脂肪组织中脂联素、脂联素受体和β 3-肾上腺素受体mRNA表达降低，CL-316，243恢复了这些mRNA表达。同时，CL-316，243抑制附睾白色脂肪组织和棕色脂肪组织中TNF-α的过表达mRNA水平。这些数据表明脂联素、脂联素受体和TNF-α的正常化可能导致肥胖诱导的胰岛素抵抗的改善。(c)2008 Elsevier B. V.保留所有权利。
We investigated the effects of beta(3)-adrenoceptor agonist, 5-[(2R)-2-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylate (CL-316,243) in obese diabetic KKAy mice. Two weeks' subcutaneous administration of CL-316,243 reduced serum levels of glucose, insulin, triglyceride, free fatty acid and tumor necrosis factor-alpha (TNF-alpha), and increased adiponectin. Adiponectin, adiponectin receptors and beta(3)-adrenoceptor mRNA expressions were reduced in epididymal white adipose tissue in KKAy mice, and CL-316,243 recovered these mRNA expressions. Meanwhile, CL-316,243 suppressed the overexpressed mRNA level of TNF-alpha in both epididymal white adipose tissue and brown adipose tissue. These data suggest that the normalization of adiponectin, adiponectin receptors and TNF-alpha may result in the amelioration of obesity-induced insulin resistance. (c) 2008 Elsevier B.V. All rights reserved.