THE PROLACTIN GENE IS LOCATED ON CHROMOSOME-6 IN HUMANS
THE PROLACTIN GENE IS LOCATED ON CHROMOSOME-6 IN HUMANS
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DOI：
10.1126/science.7221563
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发表时间：
1981-01-01
期刊：
影响因子：
56.9
通讯作者：
SHOWS, TB
中科院分区：
文献类型：
--
作者：
OWERBACH, D;RUTTER, WJ;SHOWS, TB
人类的催乳素基因位于6号染色体上。在人类基因组DNA中分别鉴定出含有催乳素基因序列的4.8和4.0碱基的DNA片段；在小鼠细胞中发现了含有催乳素基因序列的7.4、3.6和3.3个碱基的DNA片段。在人和小鼠的体细胞杂交中，始终存在7.4、3.6和3.3 kbase的小鼠片段；4.8和4.0碱基的人类片段只有在人类6号染色体也存在时才存在。催乳素基因位于6号染色体上，与相关激素绒毛膜、促生长激素和生长激素的基因位置不同。
The gene for prolactin was located on chromosome 6 in humans. DNA fragments of 4.8 and 4.0 kbases containing prolactin gene sequences were identified in human genomic DNA; DNA fragments of 7.4, 3.6 and 3.3 kbases containing prolactin gene sequences were found in mouse cells. In somatic cell hybrids of human and mouse cells the 7.4, 3.6 and 3.3 kbase mouse fragments were always present; the 4.8 and 4.0 kbase human fragments were only present when human chromosome 6 was also present. The prolactin gene resides on chromosome 6, a different location from those of the genes for the related hormones chorionic somatomammotropin and growth hormone.