MRI with diffusion tensor imaging post-mortem at 3.0 T in a patient with frontotemporal dementia
MRI with diffusion tensor imaging post-mortem at 3.0 T in a patient with frontotemporal dementia
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DOI：
10.1159/000077162
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发表时间：
2004-01-01
影响因子：
2.4
通讯作者：
Brockstedt, S
中科院分区：
文献类型：
--
作者：
Larsson, EM;Englund, E;Brockstedt, S
采用3.0 T磁共振成像（MRI）和扩散张量成像（DTI）对临床诊断为额颞叶痴呆（FTD）的患者福尔马林固定的大脑进行尸检。观察到额颞萎缩以及双侧额叶白色物质异常。白色改变在DTI上比在常规MRI上稍广泛。与相应区域的组织病理学相关性显示典型的非阿尔茨海默型额叶变性，外皮质层轻度额颞叶变性和中度额叶白色物质胶质增生伴脱髓鞘。尸检MRI/DTI与组织病理学相关性将增强我们对痴呆患者中观察到的白色物质变化基础的理解，并可能改善FTD的体内MRI/DTI诊断评估。版权所有（C）2004 S. Karger AG，巴塞尔。
The formalin-fixed brain of a patient with clinically diagnosed frontotemporal dementia (FTD) was examined post-mortem using magnetic resonance imaging (MRI) with diffusion tensor imaging (DTI) at 3.0 T. Frontotemporal atrophy as well as bilateral frontal white matter abnormalities were seen. The white matter changes were slightly more extensive on DTI than on conventional MRI. Correlation with histopathology of the corresponding regions revealed typical frontal lobe degeneration of non-Alzheimer type, with mild frontotemporal degeneration in the outer cortical layers and a moderate frontal white matter gliosis with demyelination. Postmortem MRI/DTI with histopathologic correlation will enhance our understanding of the basis of white matter changes observed in dementia patients and may improve the in vivo MRI/DTI diagnostic assessment in FTD. Copyright (C) 2004 S. Karger AG, Basel.