Multifunctional Graphene-PEDOT Microelectrodes for On Chip Manipulation of Human Mesenchymal Stem Cells
Multifunctional Graphene-PEDOT Microelectrodes for On Chip Manipulation of Human Mesenchymal Stem Cells
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DOI：
10.1002/adfm.201203631
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发表时间：
2013-10-04
影响因子：
19
通讯作者：
Chen, Peilin
中科院分区：
文献类型：
--
作者：
Hsiao, Yu-Sheng;Kuo, Chiung-Wen;Chen, Peilin
报道了由还原氧化石墨烯（rGO）和地塞米松21-磷酸二钠盐（DEX）负载的聚（3，4-乙撑二氧噻吩）（PEDOT）微电极阵列在氧化铟锡玻璃上构成的全溶液处理多功能有机生物电子学。它们可用于操纵人间充质干细胞（hMSCs）的分化。在该装置中，rGO材料用作粘合剂涂层，以促进hMSC细胞的粘附和排列，并加速其成骨分化。聚（L-赖氨酸-接枝-乙二醇）（PLL-g-PEG）涂层PEDOT电极作为电活性药物释放电极。此外，相应的三区平行装置通过从PEDOT基质中释放药物DEX的时空控制作为有效的药物释放组件操作。这种装置可用于长期细胞培养和通过电刺激控制hMSC的分化。
All-solution-processed multifunctional organic bioelectronics composed of reduced graphene oxide (rGO) and dexamethasone 21-phosphate disodium salt (DEX)-loaded poly(3,4-ethylenedioxythiophene) (PEDOT) microelectrode arrays on indium tin oxide glass are reported. They can be used to manipulate the differentiation of human mesenchymal stem cells (hMSCs). In the devices, the rGO material functions as an adhesive coating to promote the adhesion and alignment of hMSC cells and to accelerate their osteogenic differentiation. The poly(L-lysine-graft-ethylene glycol) (PLL-g-PEG)-coated PEDOT electrodes serve as electroactive drug-releasing electrodes. In addition, the corresponding three-zone parallel devices operate as efficient drug-releasing components through spatial-temporal control of the release of the drug DEX from the PEDOT matrix. Such devices can be used for long-term cell culturing and controlled differentiation of hMSCs through electrical stimulation.