Life extension in Drosophila by feeding a drug
Life extension in Drosophila by feeding a drug
复制标题
DOI：
10.1073/pnas.022631999
复制
发表时间：
2002-01-22
影响因子：
11.1
通讯作者：
Min, KT
中科院分区：
文献类型：
--
作者：
Kang, HL;Benzer, S;Min, KT
我们报告说，在整个成年期喂养果蝇与4-苯基丁酸（PBA）可以显着增加寿命，而不减少运动活力，抗应激能力，或生殖能力。在有限的时间内治疗，无论是成年早期还是晚期，也是有效的。喂食PBA的果蝇显示组蛋白乙酰化的整体增加以及基因表达模式的显著改变，包括许多基因的诱导或抑制。衰老的延迟可能是由于生理状态的改变。
We report that feeding Drosophila throughout adulthood with 4-phenylbutyrate (PBA) can significantly increase lifespan, without diminution of locomotor vigor, resistance to stress, or reproductive ability. Treatment for a limited period, either early or late in adult life, is also effective. Flies fed PBA show a global increase in histone acetylation as well as a dramatically altered pattern of gene expression, including induction or repression of numerous genes. The delay in aging may result from the altered physiological state.