The effect of fresh frozen plasma in severe closed head injury
The effect of fresh frozen plasma in severe closed head injury
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DOI：
10.1016/j.clineuro.2006.09.001
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发表时间：
2007-02-01
影响因子：
1.9
通讯作者：
Ganjeifar, Babak
中科院分区：
文献类型：
--
作者：
Etemadrezaie, Hamid;Baharvahdat, Humain;Ganjeifar, Babak
目的：创伤性脑损伤（Traumatic brain injury，TBI）是最常见的致残和致死原因之一。严重脑外伤后常见的凝血病与预后不良和继发性并发症有关，尤其是迟发性创伤性脑内血肿（DTICH）。在这项研究中，我们评估了新鲜冷冻血浆（FFP）对减少DTICH在严重闭合性颅脑损伤victims.Methods的发病率的影响：本研究进行了双盲随机临床试验。90例患者分为两个平行组，分别服用FFP或生理盐水（N/S）。两组患者的选择标准均为：重度闭合性颅脑损伤（格拉斯哥昏迷评分
Objective: Traumatic brain injury (TBI) is one of the most common causes of morbidity and mortality. Coagulopathy, commonly occurring after severe TBI, is associated with poor outcome and secondary complications, especially delayed traumatic intracerebral hematoma (DTICH). In this study we evaluated the effect of fresh frozen plasma (FFP) on the reduction in the incidence of DTICH in severe closed head injury victims.Methods: This study was carried out as a double-blind randomized clinical trial. Ninety patients were entered in two parallel groups taking either FFP or normal saline (N/S). Patients' selection criteria for both groups were: severe closed head injury (Glasgow coma scale