Variation of Metabolite and Hormone Contents in Human Milk
Variation of Metabolite and Hormone Contents in Human Milk
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DOI：
10.1016/j.clp.2016.11.007
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发表时间：
2017-03-01
影响因子：
2.1
通讯作者：
Koletzko, Berthold
中科院分区：
文献类型：
--
作者：
Demmelmair, Hans;Koletzko, Berthold
动物研究表明，哺乳期有助于后代的代谢编程，口服瘦素和胰岛素具有生物活性。哺乳期、孕期、母体成分和母体饮食似乎会影响母乳中小分子物质的浓度。早产乳小分子浓度的变异性似乎比足月乳高。母乳中的胰岛素浓度与血浆中的胰岛素浓度相似。牛奶中的瘦素浓度低于血浆中的瘦素浓度，并反映了孕妇的体重指数。在哺乳期早期，瘦素可能有助于调节母婴身体成分之间的联系。
Animal studies show that the lactation period contributes to metabolic programming of the offspring and that oral leptin and insulin show bioactivity. Stage of lactation, duration of gestation, maternal body composition, and maternal diet seem to influence the concentrations of small molecules in human milk. Variability of small molecule concentrations seems higher in pre term milk than in term milk. Insulin in human milk shows concentrations similar to plasma. Leptin concentration is lower in milk than in plasma and reflects maternal body mass index. Early in lactation, leptin could contribute to mediating the association between maternal and infant body composition.