No effect of nutritional adenosine receptor antagonists on exercise performance in the heat
No effect of nutritional adenosine receptor antagonists on exercise performance in the heat
复制标题
DOI：
10.1152/ajpregu.90812.2008
复制
发表时间：
2009-02-01
影响因子：
2.8
通讯作者：
Sawka, Michael N.
中科院分区：
文献类型：
--
作者：
Cheuvront, Samuel N.;Ely, Brett R.;Sawka, Michael N.
Cheuvront SN，伊利BR，Kenefick RW，Michniak-Kohn BB，Rood JC，Sawka MN.营养性腺苷受体拮抗剂对高温下的运动表现无影响。Am J Physiol Regul Integr Comp Physiol 296：R394-R401，2009。首次发表于2008年11月19日; doi：10.1152/ajpregu.90812.2008。营养性腺苷受体拮抗剂可以提高在温和环境中的耐力运动表现，但其在热应激中的功效还不清楚。这项双盲、安慰剂对照研究比较了急性剂量的咖啡因或槲皮素对可补偿热应激（40摄氏度，20-30%相对湿度）期间耐力运动表现的影响。在这三种情况下，10名健康男性分别进行了30分钟的踏车测力计，在50%（V）超过点O-2峰值，然后进行了15分钟的性能时间试验后，接受安慰剂（P组），咖啡因（C组; 9 mg/kg），或槲皮素（Q组; 2,000 mg）。连续血液样本，生理（心率，直肠和平均皮肤体温），知觉（感知的努力，疼痛，热舒适，动机的评级），和运动性能的措施（总工作和起搏策略）。补充咖啡因和槲皮素增加运动前的血液浓度的咖啡因（55.62 +/- 4.77 μ M）和槲皮素（4.76 +/- 2.56 μ M）以上的腺苷受体的体外抑制常数。除直肠体温升高外，未观察到任何生理或感知指标的治疗效应（0.20-0.30 ℃; P < 0.05），C组与Q组和P组相比。（P组：153.5 ± 28.3，C组：157.3 ± 28.9，Q组：151.1 ± 31.6 kJ; P > 0.05）或所采用的自选起搏策略。这些结果表明，营养腺苷受体拮抗剂咖啡因和槲皮素不提高耐力运动的表现在补偿热应激。
Cheuvront SN, Ely BR, Kenefick RW, Michniak-Kohn BB, Rood JC, Sawka MN. No effect of nutritional adenosine receptor antagonists on exercise performance in the heat. Am J Physiol Regul Integr Comp Physiol 296: R394-R401, 2009. First published November 19, 2008; doi: 10.1152/ajpregu.90812.2008.-Nutritional adenosine receptor antagonists can enhance endurance exercise performance in temperate environments, but their efficacy during heat stress is not well understood. This double-blinded, placebo-controlled study compared the effects of an acute dose of caffeine or quercetin on endurance exercise performance during compensable heat stress (40 degrees C, 20-30% rh). On each of three occasions, 10 healthy men each performed 30-min of cycle ergometry at 50% (V) over dot O-2peak followed by a 15-min performance time trial after receiving either placebo (Group P), caffeine (Group C; 9 mg/kg), or quercetin (Group Q; 2,000 mg). Serial blood samples, physiological (heart rate, rectal, and mean skin body temperatures), perceptual (ratings of perceived exertion, pain, thermal comfort, motivation), and exercise performance measures (total work and pacing strategy) were made. Supplementation with caffeine and quercetin increased preexercise blood concentrations of caffeine (55.62 +/- 4.77 mu M) and quercetin (4.76 +/- 2.56 mu M) above their in vitro inhibition constants for adenosine receptors. No treatment effects were observed for any physiological or perceptual measures, with the exception of elevated rectal body temperatures (0.20-0.30 degrees C; P < 0.05) for Group C vs. Groups Q and P. Supplementation did not affect total work performed (Groups P: 153.5 +/- 28.3, C: 157.3 +/- 28.9, and Q: 151.1 +/- 31.6 kJ; P > 0.05) or the self-selected pacing strategy employed. These findings indicate that the nutritional adenosine receptor antagonists caffeine and quercetin do not enhance endurance exercise performance during compensable heat stress.