Perceptual functions of perirhinal cortex in rats: Zero-delay object recognition and simultaneous oddity discriminations
Perceptual functions of perirhinal cortex in rats: Zero-delay object recognition and simultaneous oddity discriminations
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DOI：
10.1523/jneurosci.5171-06.2007
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发表时间：
2007-03-07
影响因子：
5.3
通讯作者：
Bussey, Timothy J.
中科院分区：
文献类型：
--
作者：
Bartko, Susan J.;Winters, Boyer D.;Bussey, Timothy J.
周围的皮质（PRH）被广泛接受为在人类和动物的对象识别记忆中起重要作用。与声称PRH专门介导声明性记忆的说法相反，先前的证据表明，PRH在复杂对象的感知处理中起作用。在本研究中，我们对PRH在大鼠感知功能中的可能作用进行了检查。我们检查了大鼠中PRH或PPRH的双侧兴奋性病变是否会导致零 - 固定对象识别任务和同时奇怪歧视任务的缺陷。这两个任务均测量了自发（未经训练，未得到回报）的行为，并且操纵这些实验中的刺激以产生不同水平的感知难度。通过使用计算模型进行的模拟预测，当操纵要歧视的刺激以共享许多共同特征时，具有PPRH病变的大鼠在物体识别中受到损害。此外，当要歧视的刺激被明确操纵时，具有PPRH和PRH病变的大鼠在同时奇怪的歧视任务中受到了损害。这些发现为大鼠中的PRH对复杂对象的感知处理很重要的想法提供了支持。
The perirhinal cortex (PRh) is widely accepted as having an important role in object recognition memory in humans and animals. Contrary to claims that PRh mediates declarative memory exclusively, previous evidence suggests that PRh has a role in the perceptual processing of complex objects. In the present study, we conducted an examination of the possible role of PRh in perceptual function in rats. We examined whether bilateral excitotoxic lesions of PRh or PPRh(perirhinal plus postrhinal cortices) in the rat would cause deficits in a zero-delay object-recognition task and a simultaneous oddity discrimination task. Both of these tasks measured spontaneous (untrained, unrewarded) behavior, and the stimuli in these experiments were manipulated to produce varying levels of perceptual difficulty. As predicted by simulations using a computational model, rats with PPRh lesions were impaired in object recognition when the stimuli to be discriminated were manipulated to share many features in common. Furthermore, rats with PPRh and PRh lesions were impaired in a simultaneous oddity discrimination task when the stimuli to be discriminated were manipulated explicitly to be more perceptually similar. These findings provide support for the idea that PRh in the rat is important for the perceptual processing of complex objects, in addition to its well established role in memory.