Sexual Dimorphisms in the Transcriptomes of Murine Salivary Glands
Sexual Dimorphisms in the Transcriptomes of Murine Salivary Glands
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小鼠唾液腺转录组的性别二态性
DOI：
10.1002/2211-5463.12625
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发表时间：
2019
期刊：
影响因子：
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通讯作者：
James E Melvin
中科院分区：
文献类型：
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作者：
Taro Mukaibo;Xin Gao;Ning-Yan Yang;Maria S Oei;Tetsuji Nakamoto;James E Melvin
转录图谱在小鼠的三个主要唾液腺：腮腺、舌下腺和颌下腺中表达的14371个蛋白质编码基因中，发现了933个性二态基因。大多数(89%)性别特异基因在单个腺体中富含，而只有0.5%的性别二态基因在所有腺体中富含。舌下腺表现出强烈的男性性别偏见(94%的性丰富基因)，而腮腺或颌下腺的性别偏好不明显。转录因子基因的一个子集与腺体特异的、性别丰富的基因的表达相关。在男性下颌下，CFTR氯和Scnn1钠通道的高表达与更大的氯化钠重吸收相关。总而言之，成人唾液腺在基因表达上表现出性别和腺体特有的差异，这反映了它们独特的功能特性。
Transcriptional profiling identified 933 sexually dimorphic genes out of the 14 371 protein‐coding genes expressed in the three major murine salivary glands: parotid, sublingual, and submandibular. Most (89%) sex‐specific genes were enriched in a single gland, while only 0.5% of the sexually dimorphic genes were enriched in all glands. The sublingual gland displayed a strong male sex bias (94% of sex‐enriched genes), while a sex preference was not obvious in the parotid or submandibular glands. A subset of transcription factor genes was correlated with the expression of gland‐specific, sex‐enriched genes. Higher expression of Cftr chloride and Scnn1 sodium channels in the male submandibular correlated with greater NaCl reabsorption. In conclusion, adult salivary glands display sex‐ and gland‐specific differences in gene expression that reflect their unique functional properties.