Mechanism of disease in early osteoarthritis: application of modern MR imaging techniques - a technical report
Mechanism of disease in early osteoarthritis: application of modern MR imaging techniques - a technical report
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DOI：
10.1016/j.mri.2012.07.005
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发表时间：
2013-01-01
影响因子：
2.5
通讯作者：
Majumdar, Sharmila
中科院分区：
文献类型：
--
作者：
Jobke, Bjoem;Bolbos, Radu;Majumdar, Sharmila
在退行性和炎症性关节疾病的早期软骨变化在总体形态变化变得明显之前，生物分子磁共振成像的应用变得越来越重要。在这份有限的技术报告中，我们研究了 MRI T1、T2 和 T1 rho 弛豫时间与软骨蛋白聚糖和胶原蛋白含量定量生化测量的相关性，并与组织学形态密切相关。最近开发的 MRI 序列 T1 rho 能够定量检测早期软骨内变性，还可以通过颜色映射定性检测，显示出比标准 T2 加权序列更高的灵敏度。通过生物化学和组织学测量，结果与蛋白聚糖含量减少和胶原蛋白结构破坏高度相关。这些发现为临床实施提供了支持，该临床实施可以在局部毫米级上快速视觉捕获病理。目前和未来的骨科治疗决策需要有关关节软骨质量的更多信息，否则无法通过正常检查在体内检测到。 (C) 2013 Elsevier Inc. 保留所有权利。
The application of biomolecular magnetic resonance imaging becomes increasingly important in the context of early cartilage changes in degenerative and inflammatory joint disease before gross morphological changes become apparent. In this limited technical report, we investigate the correlation of MRI T1, T2 and T1 rho relaxation times with quantitative biochemical measurements of proteoglycan and collagen contents of cartilage in close synopsis with histologic morphology. A recently developed MRI sequence, T1 rho, was able to detect early intracartilaginous degeneration quantitatively and also qualitatively by color mapping demonstrating a higher sensitivity than standard T2-weighted sequences. The results correlated highly with reduced proteoglycan content and disrupted collagen architecture as measured by biochemistry and histology. The findings lend support to a clinical implementation that allows rapid visual capturing of pathology on a local, millimeter level. Further information about articular cartilage quality otherwise not detectable in vivo, via normal inspection, is needed for orthopedic treatment decisions in the present and future. (C) 2013 Elsevier Inc. All rights reserved.