Deficient attentional modulation of startle eyeblink is associated with symptom severity in the schizophrenia spectrum
Deficient attentional modulation of startle eyeblink is associated with symptom severity in the schizophrenia spectrum
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DOI：
10.1016/j.schres.2007.03.012
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发表时间：
2007-07-01
影响因子：
4.5
通讯作者：
Buchsbaum, Monte S.
中科院分区：
文献类型：
--
作者：
Hazlett, Erin A.;Romero, Michelle J.;Buchsbaum, Monte S.
精神分裂症谱系障碍患者表现出受惊眨眼反射的脉冲前抑制（PPI）缺陷，这被认为反映了被称为自动感觉运动门控的信息处理的早期阶段。他们还表现出对PPI和惊吓前脉冲促进（PPF）的注意调节缺陷，这被认为反映了早期和后期控制注意加工的缺陷。这是第一个在年龄和性别匹配的未服药的分裂型人格障碍（SPD）和精神分裂症患者以及健康对照的三组精神分裂症谱系样本中评估PPI和PPF注意调节的研究。在测量声惊眨眼反射的同时，参与者进行了一项音调长度判断任务，包括被注意的、被忽视的和新的音调预脉冲。健康对照在参加预搏期间PPI和PPF高于未参加预搏期间。相比之下，SPD和精神分裂症患者组都没有表现出这种模式，这表明早期和后期的控制注意力加工都存在缺陷。这些发现提示PPI和PPF的异常注意调节可能是精神分裂症谱系障碍患者的一种特征。在精神分裂症谱系样本中，根据总18项简短精神病学评定量表得分，参加预搏击期间PPI缺陷越多，症状严重程度越高。(c) 2007 Elsevier B.V.版权所有
Patients with schizophrenia-spectrum disorders show deficient prepulse inhibition (PPI) of the startle eyeblink reflex which is thought to reflect an early stage of information processing called automatic sensorimotor gating. They also exhibit deficient attentional modulation of PPI and prepulse facilitation (PPF) of startle which is thought to reflect deficient early and later controlled attentional processing. This is the first study to assess attentional modulation of PPI and PPF in a 3-group schizophrenia-spectrum sample of age- and sex-matched unmedicated schizotypal personality disorder (SPD) and schizophrenia patients, and healthy controls. Participants performed a tone-length judgment task involving attended, ignored, and novel tone prepulses while the acoustic startle eyeblink reflex was measured. Healthy controls showed greater PPI and PPF during the attended prepulses compared with the ignored prepulses. In contrast, both the SPD and schizophrenia patient groups failed to show this pattern, indicating deficient early and later controlled attentional processing. These findings suggest abnormal attentional modulation of PPI and PPF may be a trait-like feature found in patients with schizophrenia-spectrum disorders. Among the schizophrenia-spectrum sample, more deficient PPI during the attended prepulses was associated with greater symptom severity as measured by the total 18-item Brief Psychiatric Rating Scale score. (c) 2007 Elsevier B.V. All rights reserved.