Identification of antibiotics using small molecule variable ligand display on gold nanoparticles
Identification of antibiotics using small molecule variable ligand display on gold nanoparticles
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DOI：
10.1039/c0cc02663h
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发表时间：
2010-01-01
影响因子：
4.9
通讯作者：
Feldheim, Daniel L.
中科院分区：
文献类型：
--
作者：
Bresee, Jamee;Maier, Keith E.;Feldheim, Daniel L.
在这里，我们描述了使用简单的一锅巯基交换反应来生成混合配体包被的金纳米颗粒库，并对其进行抗生素活性筛选。组装了120个纳米颗粒缀合物的文库，并对E.大肠杆菌中，并发现依赖于组装到纳米粒子上的硫醇的组合。最具活性的缀合物在0.5 μ M时显示99.9%的生长抑制。
Here we describe the use of simple 1-pot thiol exchange reactions to generate a library of mixed ligand-coated gold nanoparticles that was screened for antibiotic activity. A library of 120 nanoparticle conjugates was assembled and antibiotic activity toward E. coli was determined and found to depend upon the combination of thiols assembled onto the nanoparticles. The most active conjugate displayed 99.9% growth inhibition at 0.5 mu M.