Hepatitis E virus and chronic hepatitis in organ-transplant recipients.
Hepatitis E virus and chronic hepatitis in organ-transplant recipients.
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DOI：
10.1056/nejmoa0706992
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发表时间：
2008-02-21
影响因子：
158.5
通讯作者：
Rostaing, Lionel
中科院分区：
文献类型：
--
作者：
Kamar, Nassim;Selves, Janick;Rostaing, Lionel
戊型肝炎病毒（HEV）被认为是一种不会进展为慢性肝炎的急性肝炎的病原体。我们确定了14例急性戊型肝炎病毒感染，其中3例接受肝移植，9例接受肾移植，2例接受肾和胰腺移植。所有患者血清HEVRNA均为阳性。8例患者发生慢性肝炎，经持续升高的转氨酶水平、血清HEV RNA和慢性肝炎的组织学特征证实。从移植到诊断的时间显着缩短，淋巴细胞和CD2，CD3和CD4 T细胞的总计数显着降低的患者中，慢性疾病的发展。
Hepatitis E virus (HEV) is considered an agent responsible for acute hepatitis that does not progress to chronic hepatitis. We identified 14 cases of acute HEV infection in three patients receiving liver transplants, nine receiving kidney transplants, and two receiving kidney and pancreas transplants. All patients were positive for serum HEV RNA. Chronic hepatitis developed in eight patients, as confirmed by persistently elevated aminotransferase levels, serum HEV RNA, and histologic features of chronic hepatitis. The time from transplantation to diagnosis was significantly shorter and the total counts of lymphocytes and of CD2, CD3, and CD4 T cells were significantly lower in patients in whom chronic disease developed.