Performance predictors of brain-computer interfaces in patients with amyotrophic lateral sclerosis
Performance predictors of brain-computer interfaces in patients with amyotrophic lateral sclerosis
复制标题
肌萎缩侧索硬化症患者脑机接口的性能预测指标
DOI：
10.1088/1741-2560/13/2/026002
复制
发表时间：
2016-04-01
影响因子：
4
通讯作者：
Schiff, S. J.
中科院分区：
文献类型：
--
作者：
Geronimo, A.;Simmons, Z.;Schiff, S. J.
目标。肌萎缩侧索硬化症（ALS）患者可能受益于脑机接口（BCI），但这种设备的效用可能必须考虑到这种神经退行性疾病的功能、认知和行为异质性。的方法。在这项研究中，一组异质性的ALS患者参与了一项基于P300事件相关电位和运动意象的脑机接口研究。结果。在这些患者中，认知障碍的存在显著降低了使用这些通信系统所需的控制信号的质量，随后损害了表现，无论身体症状的进展如何。认知功能受损者的表现下降伴随着与任务相关的脑电图频带功率的信噪比下降。也有证据表明，行为障碍会对P300拼写者的表现产生负面影响。最后，年龄较大的参与者在P300系统上的表现优于运动-意象系统，这表明脑机接口模式随着年龄的增长而受到偏爱。的意义。这些发现强调了在设计脑机接口辅助和替代通信设备用于临床应用时考虑疾病异质性的重要性。
Objective. Patients with amyotrophic lateral sclerosis (ALS) may benefit from brain-computer interfaces (BCI), but the utility of such devices likely will have to account for the functional, cognitive, and behavioral heterogeneity of this neurodegenerative disorder. Approach. In this study, a heterogeneous group of patients with ALS participated in a study on BCI based on the P300 event related potential and motor-imagery. Results. The presence of cognitive impairment in these patients significantly reduced the quality of the control signals required to use these communication systems, subsequently impairing performance, regardless of progression of physical symptoms. Loss in performance among the cognitively impaired was accompanied by a decrease in the signal-to-noise ratio of task-relevant EEG band power. There was also evidence that behavioral dysfunction negatively affects P300 speller performance. Finally, older participants achieved better performance on the P300 system than the motor-imagery system, indicating a preference of BCI paradigm with age. Significance. These findings highlight the importance of considering the heterogeneity of disease when designing BCI augmentative and alternative communication devices for clinical applications.