DDT and DDE exposure in mothers and time to pregnancy in daughters
DDT and DDE exposure in mothers and time to pregnancy in daughters
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DOI：
10.1016/s0140-6736(03)13776-2
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发表时间：
2003-06-28
期刊：
影响因子：
168.9
通讯作者：
Siiteri, PK
中科院分区：
文献类型：
--
作者：
Cohn, BA;Cirillo, PM;Siiteri, PK
孕妇在服用强效雌激素己烯雌酚后出现生殖道异常，令人担忧暴露于弱雌激素环境污染物，如双[4-氯苯基]-1，1，1-三氯乙烷(p，p‘-DDT)或其代谢物，如双[4-氯苯基]-1，1-二氯乙烯(p，p’-DDE)的生殖影响。我们测定了1960年至1963年分娩后1-3天采集的保存的孕妇血清样本中的p，p‘-DDT和p，p’-DDE。28-31年后，我们记录了289名大女儿的怀孕时间。女婴受孕概率每10杯下降32%/L，母亲血清中p，p‘-滴滴涕(95%CI 11-48)。相比之下，每10杯L的受孕几率增加了16%。与产前p，p‘-DDT相关的受精率下降仍未得到解释。我们推测，p，p‘-DDE的抗雄激素活性可能减轻孕期或生命早期对卵巢的有害雄激素影响。
Reproductive-tract anomalies after administration of the potent oestrogen, diethylstilboestrol, in pregnant women raised concerns about the reproductive effects of exposure to weakly oestrogenic environmental contaminants such as bis[4-chlorophenyl]-1,1,1-trichloroethane (p,p'-DDT) or its metabolites, such as bis[4-chlorophenyl]-1,1-dichloroethene (p,p'-DDE). We measured p,p'-DDT and p,p'-DDE in preserved maternal serum samples drawn 1-3 days after delivery between 1960 and 1963. We recorded time to pregnancy In 289 eldest daughters 28-31 years later. Daughters' probability of pregnancy fell by 32% per 10 mug/L p,p'-DDT in maternal serum (95% CI 11-48). By contrast, the probability of pregnancy increased 16% per 10 mug/L p,p'-DDE (6-27). The decreased fecundability associated with prenatal p,p'-DDT remains unexplained. We speculate that the antiandrogenic activity of p,p'-DDE may mitigate harmful androgen effects on the ovary during gestation or early life.