MICROGLIA EXPRESS THE TYPE-2 PLASMINOGEN-ACTIVATOR INHIBITOR IN THE BRAIN OF CONTROL SUBJECTS AND PATIENTS WITH ALZHEIMERS-DISEASE
MICROGLIA EXPRESS THE TYPE-2 PLASMINOGEN-ACTIVATOR INHIBITOR IN THE BRAIN OF CONTROL SUBJECTS AND PATIENTS WITH ALZHEIMERS-DISEASE
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DOI：
10.1016/0304-3940(93)90899-v
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发表时间：
1993-12-24
影响因子：
2.5
通讯作者：
MCGEER, PL
中科院分区：
文献类型：
--
作者：
AKIYAMA, H;IKEDA, K;MCGEER, PL
用免疫组织化学方法研究了2型纤溶酶原激活物抑制物(PAI-2)在正常对照组和阿尔茨海默病(AD)患者死后脑组织中的分布。小鼠抗PAI-2多克隆抗体和抗PAI-2多克隆抗体均为阳性。反应性小胶质细胞比静息状态的小胶质细胞染色更深。PAI-2对AD皮损中纤溶酶原激活物和纤溶酶系统可能有调节作用。提示PAI-2在细胞迁移和基质分解以及在观察到持续的小胶质细胞激活的老年斑中异常的轴突生长中起作用。
Localization of type 2 plasminogen activator inhibitor (PAI-2) was investigated immunohistochemically in postmortem brain tissue of control subjects and patients with Alzheimer's disease (AD). Both the mouse monoclonal and the goat polyclonal antibodies to PAI-2 stained microglia. Reactive microglia were stained more intensely than resting microglia. PAI-2 may regulate the plasminogen activators and plasmin system in lesions of AD. It is suggested that PAI-2 plays a role for cell migration and matrix breakdown as well as for aberrant neurite outgrowth in senile plaques where persistent microglial activation is observed.