Invasive group A streptococcal disease: should close contacts routinely receive antibiotic prophylaxis?
Invasive group A streptococcal disease: should close contacts routinely receive antibiotic prophylaxis?
复制标题
侵袭性 A 组链球菌疾病：密切接触者是否应该常规接受抗生素预防？
DOI：
10.1016/s1473-3099(05)70190-0
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发表时间：
2005
期刊：
影响因子：
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通讯作者：
James M. Stuart
中科院分区：
文献类型：
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作者：
A. Smith;Theresa Lamagni;I. Oliver;Androulla Efstratiou;Robert George;James M. Stuart
A 组链球菌（化脓性链球菌）可引起多种疾病，从非侵袭性疾病（例如咽炎）到更严重的侵袭性感染（例如坏死性筋膜炎和中毒性休克样综合征）。指示病例的密切接触者中发生侵袭性疾病继发病例的风险以及如何最好地管理该风险仍存在不确定性。我们认为，目前现有的证据不足以证明对密切接触者进行常规化学预防是合理的。我们建议，适当的应对措施应该是定期告知 A 族链球菌疾病患者的所有家庭接触者有关侵袭性疾病的临床表现，并在出现此类症状时立即就医。
Group A streptococci (Streptococcus pyogenes) causes a wide range of illnesses from non-invasive disease—eg, pharyngitis—to more severe invasive infections—eg, necrotising fasciitis and toxic shock-like syndrome. There remains uncertainty about the risk of secondary cases of invasive disease occurring among close contacts of an index case and how best to manage that risk. We do not consider that currently available evidence justifies the routine administration of chemoprophylaxis to close contacts. We suggest that the appropriate response should be to routinely inform all household contacts of a patient with invasive group A streptococcal disease about the clinical manifestations of invasive disease and to seek immediate medical attention if they develop such symptoms.