Ribosomal protein S6 kinase is activated after folic acid injury and epidermal growth factor administration but not after unilateral nephrectomy in the rat kidney.
Ribosomal protein S6 kinase is activated after folic acid injury and epidermal growth factor administration but not after unilateral nephrectomy in the rat kidney.
复制标题
核糖体蛋白 S6 激酶在叶酸损伤和给予表皮生长因子后被激活，但在大鼠肾脏的单侧肾切除术后不被激活。
作者：
P. Alberti;L. Bardella;R. Comolli
单次胃肠外注射叶酸诱导功能性肾脏质量丧失后，肾小管上皮细胞增殖增加以取代损伤和坏死的细胞，这与体外S6激酶激活和该核糖体蛋白磷酸化增强有关，1.5小时后给予EGF。叶酸促进S6蛋白的磷酸化并加速再生修复过程。相反，单侧肾切除术后肾脏的肥大反应与S6激酶激活无关。这项研究的结果表明，S6蛋白磷酸化水平和细胞增殖的程度在大鼠肾脏之间的密切相关性。
Following loss of functional renal mass induced by a single parenteral injection of folic acid, the increased proliferation of tubular epithelium to replace injured and necrotic cells was associated with S6 kinase activation and enhanced phosphorylation of this ribosomal protein in vitro, EGF administered 1.5 h after folic acid promoted the phosphorylation of S6 protein and accelerated the regenerative repair process. In contrast, the hypertrophic response of the kidney following uninephrectomy was not associated with S6 kinase activation. The results of this study suggest a close correlation between levels of S6 protein phosphorylation and the degree of cell proliferation in the rat kidney.