Fc Gamma Receptor 3B (FCGR3B-c.233C>A-rs5030738) Polymorphism Modifies the Protective Effect of Malaria Specific Antibodies in Ghanaian Children
Fc Gamma Receptor 3B (FCGR3B-c.233C>A-rs5030738) Polymorphism Modifies the Protective Effect of Malaria Specific Antibodies in Ghanaian Children
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DOI：
10.1093/infdis/jit422
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发表时间：
2014-01-15
影响因子：
6.4
通讯作者：
Theisen, Michael
中科院分区：
文献类型：
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作者：
Adu, Bright;Jepsen, Micha Phill Gronholm;Theisen, Michael
免疫球蛋白G （IgG）与Fc γ受体IIIB交联（Fc γ RIIIB）触发中性粒细胞脱粒，释放与疟疾保护相关的高水平活性氧。FCGR3B-c。233C >一种被认为影响IgG与Fc γ RIIIB相互作用的多态性最近与疟疾有关。我们研究了谷氨酸富蛋白抗体与FCGR3B-c之间的统计相互作用。A基因型对加纳儿童疟疾风险的影响。与233CC儿童相比，233AA/AC个体的疟疾绝对风险随着抗体水平的增加而下降得更快。这种与基因型相关的效应改变可能显著影响疟疾血清流行病学和疫苗试验研究。
Immunoglobulin G (IgG) cross-linking with Fc gamma receptor IIIB (Fc gamma RIIIB) triggers neutrophil degranulation, releasing reactive oxygen species with high levels associated with protection against malaria. The FCGR3B-c.233C > A polymorphism thought to influence the interaction between IgG and Fc gamma RIIIB was recently associated with malaria. We studied the statistical interaction between glutamate rich protein antibodies and FCGR3B-c.233C > A genotypes on risk of malaria in a cohort of Ghanaian children. The absolute risk of malaria decreased more rapidly with increasing antibody levels for 233AA/AC individuals compared with 233CC children. This genotype related effect modification may significantly influence malaria sero-epidemiological and vaccine trial studies.