The Presence of HPV DNA in Neck Lymph Node Metastasis Correlates with Improved Overall Survival of Patients with Oropharyngeal Cancer Undergoing Surgical Treatment
The Presence of HPV DNA in Neck Lymph Node Metastasis Correlates with Improved Overall Survival of Patients with Oropharyngeal Cancer Undergoing Surgical Treatment
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颈部淋巴结转移中 HPV DNA 的存在与接受手术治疗的口咽癌患者总体生存率的提高相关
DOI：
10.1159/000452420
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发表时间：
2017
期刊：
影响因子：
3.5
通讯作者：
Fiji Shimura Takanori Hama
中科院分区：
文献类型：
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作者：
犬飼大輔;小川徹也ら;Fiji Shimura Takanori Hama
背景：口咽鳞状细胞癌(OPSCC)中人乳头瘤病毒(HPV)感染如何影响手术治疗效果的研究很少，此外，HPV DNA的存在与颈淋巴转移(LN)之间的关系还没有得到很好的确定。结果：HPV阳性患者的总生存率显著高于HPV阴性患者(log-ranking检验，p=0.04)，而HPV感染状态对无瘤生存率无显著影响(log-ranking检验，p=0.65)。在所有发生宫颈LN转移的HPV阳性的OPSCC患者中，原发灶和转移灶中的HPV DNA类型相同。结论：HPV感染是决定接受一线手术治疗的OPSCC患者预后的一个决定因素。
Background:Few studies have addressed how human papilloma virus (HPV) infection in oropharyngeal squamous cell carcinoma (OPSCC) affects the outcome of surgical therapy; furthermore, the relationship between the presence of HPV DNA and neck lymph node (LN) metastasis has not been well established.Methods:A total of 65 patients who underwent surgery as a first-line therapy for OPSCC were enrolled in this study. In HPV-positive patients, the presence of HPV DNA in metastatic neck LN lesions was evaluated.Results:The HPV-positive patients had significantly better overall survival than the HPV-negative patients (log-rank test,p= 0.04), whereas HPV infection status did not significantly affect disease-free survival (log-rank test,p= 0.65). In all of the HPV-positive OPSCC patients who developed cervical LN metastasis, the same HPV DNA type was found in both the primary tumour and the metastases.Conclusions:The present results suggest that HPV infection is a determining factor for good prognosis in patients undergoing first-line surgical therapy for OPSCC.