Estrogen biosynthesis proximal to a breast tumor is stimulated by PGE2 via cyclic AMP, leading to activation of promoter II of the CYP19 (aromatase) gene.
Estrogen biosynthesis proximal to a breast tumor is stimulated by PGE2 via cyclic AMP, leading to activation of promoter II of the CYP19 (aromatase) gene.
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DOI：
10.1210/endo.137.12.8940410
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发表时间：
1996-12
期刊：
影响因子：
4.8
通讯作者：
Ying Zhao;V. Agarwal;C. Mendelson;E. Simpson
中科院分区：
文献类型：
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作者：
Ying Zhao;V. Agarwal;C. Mendelson;E. Simpson
在本报告中，我们表明，前列腺素（PG）E2是最有力的因素，刺激芳香化酶的表达，通过环AMP和启动子II。PGE2通过EP1和EP2受体亚型刺激PKC和PKA途径。这两种途径的联合刺激导致启动子II特异性CYP 19转录物的最大表达。由于PGE2是乳腺肿瘤上皮细胞和成纤维细胞以及浸润肿瘤部位的巨噬细胞的主要分泌产物，因此这可能是在邻近肿瘤的乳腺部位刺激雌激素生物合成的机制，进而导致肿瘤本身的生长和发育增加。
In the present report, we show that prostaglandin (PG) E2 is the most potent factor which stimulates aromatase expression via cyclic AMP and promoter II. PGE2 acts via EP1 and EP2 receptor subtypes to stimulate both the PKC and PKA pathways. The combined stimulation of both of these pathways results in maximal expression of promoter II-specific CYP19 transcripts. Since PGE2 is a major secretory product both of breast tumor epithelial cells and fibroblasts, as well as of macrophages infiltrating the tumor site, then this could be the mechanism whereby estrogen biosynthesis is stimulated in breast sites adjacent to a tumor, leading in turn to increased growth and development of the tumor itself.