Phase-Change Materials Based Nanoparticles for Controlled Hypoxia Modulation and Enhanced Phototherapy
Phase-Change Materials Based Nanoparticles for Controlled Hypoxia Modulation and Enhanced Phototherapy
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基于相变材料的纳米颗粒用于受控缺氧调节和增强光疗
DOI：
10.1002/adfm.201906805
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发表时间：
2019
影响因子：
19
通讯作者：
Dong Xiaochen
中科院分区：
文献类型：
--
作者：
Zhang Shichao;Li Qinzhe;Yang Nan;Shi Yunhao;Ge Wei;Wang Wenjun;Huang Wei;Song Xuejiao;Dong Xiaochen
肿瘤缺氧可增强肿瘤对各种治疗的抵抗力，尤其是氧参与的治疗策略，如光动力治疗（PDT）。本文利用热响应相变材料（PCM）共封装超小二氧化锰（sMnO 2）和有机光敏剂IR 780，以获得IR 780-sMnO 2-PCM纳米颗粒，用于控制肿瘤缺氧调节和增强光疗。热响应保护层不仅可以防止IR 780的光降解，而且可以在激光照射下立即释放sMnO 2，分解内源性H2 O2，产生足够的氧气用于PDT。由于IR 780-sMnO 2-PCM纳米颗粒在静脉注射下在肿瘤中的有效积累，如荧光成像和光声成像所显示的，肿瘤缺氧大大减轻。此外，与IR 780-PCM纳米颗粒相比，在体内联合光热疗法（PTT）和PDT中，IR 780-sMnO 2-PCM纳米颗粒在抑制肿瘤生长方面表现出更好的性能。结果突出了IR 780-sMnO 2-PCM在肿瘤缺氧的受控调节中的前景，以克服当前癌症治疗的局限性。
Tumor hypoxia strengthens tumor resistance to different therapies especially oxygen involved strategies, such as photodynamic therapy (PDT). Herein, the thermal responsive phase change materials (PCM) are utilized to coencapsulate ultrasmall manganese dioxide (sMnO2) and organic photosensitizer IR780 to obtain IR780‐sMnO2‐PCM nanoparticles for controlled tumor hypoxia modulation and enhanced phototherapy. The thermal responsive protective PCM layer can not only prevent IR780 from photodegradation, but also immediately release sMnO2to decompose endogenous H2O2and generate enough oxygen for PDT under laser irradiation. Owing to the efficient accumulation of IR780‐sMnO2‐PCM nanoparticles in tumor under intravenous injection as revealed by both florescence imaging and photoacoustic imaging, the tumor hypoxia is greatly relieved. Furthermore, in vivo combined photothermal therapy (PTT) and PDT, IR780‐sMnO2‐PCM nanoparticles, compared to IR780‐PCM nanoparticles, exhibit better performance in inhibiting tumor growth. The results highlight the promise of IR780‐sMnO2‐PCM in controlled modulation of tumor hypoxia to overcome current limitations of cancer therapies.