SURGICAL RESECTION OF CAROTID-BODY TUMORS - LONG-TERM SURVIVAL, RECURRENCE, AND METASTASIS
SURGICAL RESECTION OF CAROTID-BODY TUMORS - LONG-TERM SURVIVAL, RECURRENCE, AND METASTASIS
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DOI：
10.1016/s0025-6196(12)64856-3
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发表时间：
1988-04-01
影响因子：
8.9
通讯作者：
PAIROLERO, PC
中科院分区：
文献类型：
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作者：
NORA, JD;HALLETT, JW;PAIROLERO, PC
我们回顾了20年来55例患者59个颈动脉体瘤的治疗经验，以确定手术切除的远期结果，包括远处转移率、局部复发率和长期存活率。55例患者中有52例(95%)可以完全手术切除。围手术期死亡率只有2%(59例手术中有1例)，在研究的最后10年中没有手术死亡。颈动脉体瘤切除后患者的存活率与性别和年龄匹配的对照组相当。只有一名患者(2%)在长期随访期间发生了转移性疾病。颈动脉体瘤完全切除后复发3例(6%)。所有复发肿瘤均发生在有多发性副神经节瘤或颈部副神经节瘤家族史的患者中。因此，我们主张早期手术切除所有低危患者的颈动脉体瘤。这样的早期切除最大限度地提高了治愈的可能性，并最大限度地降低了与大而被忽视的肿瘤相关的神经血管并发症的风险。
We retrospectively reviewed a 20-year experience with 59 carotid body tumors in 55 patients examined at out institution in order to determine the long-term results of surgical resection, including the rates of distant metastasis, local recurrence, and long-term survival. Complete surgical excision was possible in 52 of the 55 patients (95%). Perioperative mortality was only 2% (1 of 59 procedures), and no operative deaths occurred during the last 10 years of the study. Survival of patients after resection of a carotid body tumor was equivalent to that for sex- and age-matched control subjects. Only one patient (2%) had development of metastatic disease during long-term follow-up. Three patients (6%) had recurrence of the carotid body tumor after complete excision. All recurrent tumors were observed in patients with multiple paragangliomas or a family history of cervical paragangliomas. Therefore, we advocate early surgical resection of all carotid body tumors in low-risk patients. Such early resection maximizes the possibility of cure and minimizes the risks of neurovascular complications associated with large and neglected tumors.