Effect of supernatants derived from T lymphocyte culture in minimal change nephrotic syndrome on rat kidney capillaries.
Effect of supernatants derived from T lymphocyte culture in minimal change nephrotic syndrome on rat kidney capillaries.
复制标题
微小病变肾病综合征 T 淋巴细胞培养上清液对大鼠肾毛细血管的影响。
作者：
K. Maruyama;S. Tomizawa;N. Shimabukuro;T. Fukuda;T. Johshita;T. Kuroume
为研究微小病变型肾病综合征患者T淋巴细胞培养上清液对大鼠左肾动脉内灌注对肾毛细血管的影响。肾病患者的T淋巴细胞培养上清液可引起大鼠明显的蛋白尿和肾小球基底膜阴离子部位的减少。这些变化在接受来自健康对照组的等量上清液的大鼠中没有发生。
The effect on the kidney capillaries of T lymphocyte culture supernatants from patients with minimal change nephrotic syndrome was studied by infusion into the left renal artery of rats. The supernatants of T lymphocyte cultures from nephrotic patients induced significant proteinuria and a reduction of anionic sites in the glomerular basement membrane of the kidneys in the rats. These changes were not produced in rats receiving equivalent supernatants from healthy controls.