Systemic exposure to Porphyromonas gingivalis predicts incident stroke
Systemic exposure to Porphyromonas gingivalis predicts incident stroke
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DOI：
10.1016/j.atherosclerosis.2006.06.027
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发表时间：
2007-07-01
期刊：
影响因子：
5.3
通讯作者：
Tuomilehto, Jaakko
中科院分区：
文献类型：
--
作者：
Pussinen, Pirkko J.;Alfthan, Georg;Tuomilehto, Jaakko
牙周炎与动脉粥样硬化的风险增加有关。关于其与中风风险相关的前瞻性数据，特别是那些测量全身暴露于牙周病原体的数据，是稀缺的。我们分析了两种主要牙周病病原体的血清抗体水平是否可预测中风，病例组和对照组均被纳入一个随机的基于人群的样本中，该样本包括8911名基线年龄在30-59岁的受试者，他们于1977年在芬兰东部参加了一项心血管疾病（CVD）危险因素调查，并随访了15年。无心血管疾病的对照组（n=516）与中风病例（n=470）的性别和5岁年龄组相匹配。在基线时无心血管疾病的受试者（n=893）中，全身暴露于牙龈卟啉单胞菌会增加中风的风险：与血清阴性受试者相比，男性IgA血清阳性和女性IgG血清阳性的牙龈卟啉单胞菌的多变量比值比（OR）（95%CI）为1.63脑卒中组分别为1.06-2.50和2.30（1.39-3.78）。在从不吸烟的男性中观察到更高的OR：与血清阴性男性相比，牙龈卟啉单胞菌IgA血清阳性男性中风的多变量OR为3.31（1.31-8.40，p=0.012）。结果提示，牙龈卟啉单胞菌的全身暴露可能是脑卒中的易感因素。(c)2006爱思唯尔爱尔兰有限公司保留所有权利。
Periodontitis has been associated with an increased risk for atherosclerosis. Prospective data concerning its association with risk of stroke, especially those measuring systemic exposure to periodontal pathogens, are scarce. We analyzed if serum antibody levels to two major periodontopathogens predict stroke.The cases and the controls were nested in a random population-based sample of 8911 subjects aged 30-59 years at baseline, who participated in a cardiovascular disease (CVD) risk factor survey in Eastern Finland in 1977 and were followed for 15 years. CVD-free controls (n=516) were matched for sex and 5-year age group with stroke cases (n=470).In subjects free from CVD at baseline (n=893), systemic exposure to Porphyromonas gingivalis increased the risk of stroke: compared to seronegative subjects, men IgA-seropositive and women IgG-seropositive for P gingivalis had a multivariate odds ratio (OR) (95% CI) of 1.63 (1.06-2.50) and 2.30 (1.39-3.78) for stroke, respectively. Higher OR was observed in males, who had never smoked: compared to seronegative men, P gingivalis IgA-seropositive men had a multivariate OR of 3.31 (1.31-8.40, p=0.012) for stroke. No association between antibody levels to Actinobacillus actinomycetemcomitans and stroke was found.The results suggest that the systemic exposure to P. gingivalis may predispose to incident stroke. (c) 2006 Elsevier Ireland Ltd. All rights reserved.