Brain metastases from prostate cancer: A single-center experience
Brain metastases from prostate cancer: A single-center experience
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DOI：
10.5152/tud.2018.74555
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发表时间：
2019-07-01
影响因子：
1.3
通讯作者：
Koc, Mehmet
中科院分区：
文献类型：
--
作者：
Kanyilmaz, Gul;Aktan, Meryem;Koc, Mehmet
目的：前列腺癌脑转移是一种罕见的疾病，文献报道很少。本研究旨在评估前列腺癌脑转移瘤在男性其他脑转移瘤中的比例，评估这些转移灶的分布、模式和磁共振成像（MRI）表现，以及前列腺癌患者脑转移瘤的预后。材料和方法：回顾性分析了2010年1月至2016年11月期间在我科接受放射治疗的339名男性。在对患者数据进行首次评估后，我们仅回顾了前列腺癌脑转移患者。我们评估了脑转移病灶的MRI特征和患者的特点，肿瘤和治疗models.Results：10 339例（2.9%）有脑转移的前列腺癌。60%的患者有单纯脑实质内转移，20%的患者有单纯广泛硬膜转移，20%的患者两者都有。脑实质内转移的患者中，75%有多发转移灶。所有患者的前列腺特异性抗原（PSA）水平中位数为49.40 ng/mL，Gleason评分>= 7。60%的患者在诊断前列腺癌时有远处转移。脑转移患者的中位生存时间为4.5个月。结论：前列腺癌脑转移灶的影像学表现多样，很难与其他类型肿瘤脑转移灶相鉴别。存在播散性疾病、高PSA水平和高Gleason评分可作为预测前列腺癌脑转移的有用参数。
Objective: Metastases from prostate cancer to the brain are very unusual and very few case series have been reported in the literature. Present study was performed to assess the proportion of brain metastasis from prostate cancer among other brain metastasis in men, to evaluate the distribution, pattern and magnetic resonance imaging (MRI) appearance of these metastatic lesions, and prognosis of brain metastasis in patients with prostate cancer.Material and methods: Between January 2010 and November 2016, 339 males who had received radiotherapy at our department were retrospectively reviewed. After the first evaluation of patients data, we reviewed only the patients with brain metastases from prostate cancer. We evaluated MRI characteristics of metastatic brain lesions and characteristics of the patients, tumor and treatment modalities.Results: Ten of 339 patients (2.9%) had brain metastases from prostate cancer. Sixty percent of the patients had pure intraparenchymal metastasis, 20% of the patients had pure extensive dural metastasis and 20% of them had both. Seventy-five percent of the patients with intraparenchymal metastasis had multiple metastatic lesions. The median prostate specific antigen (PSA) level was 49.40 ng/mL and the Gleason score was >= 7 in all patients. Sixty percent of the patients had distant metastasis at the time of the diagnosis of prostate cancer. Median survival time in patients with brain metastasis was 4.5 months.Conclusion: Lesions of brain metastasis from prostate cancer had a large variety of imaging presentation and it is very difficult to distinguish them from the other brain metastasis originating from other types of cancer. Presence of a disseminated disease, high PSA level and high Gleason score can be useful parameters for the prediction of brain metastasis from prostate cancer.