A novel approach to defining the relationship between lung function and symptom status in asthma.
A novel approach to defining the relationship between lung function and symptom status in asthma.
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DOI：
10.1016/s0895-4356(01)00412-7
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发表时间：
2002
影响因子：
7.2
通讯作者：
Karen M. Kuntz;Barrett T. Kitch;A. Fuhlbrigge;A. Paltiel;Scott T. Weiss
中科院分区：
文献类型：
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作者：
Karen M. Kuntz;Barrett T. Kitch;A. Fuhlbrigge;A. Paltiel;Scott T. Weiss
我们提出了一种新的方法来估计1秒用力呼气量(FEV1)和哮喘相关症状之间的功能关系。我们使用了与哮喘相关的临床试验，报告了对平均肺功能(以FEV1%预测的方式测量)和症状(症状评分或症状天数或夜间觉醒的百分比)的估计。在加权线性回归分析中，使用每项研究的平均基线值，我们发现肺功能与症状评分(P<；0.001)和夜间觉醒百分比(P=0.18)呈负相关，但肺功能与症状天数之间没有相关性。我们还发现，在这些研究中，肺功能的平均变化与随访时的症状之间存在一致的关系。FEV1预测百分比和哮喘相关症状之间的函数关系可用于推断与总体肺功能改善相关的人群症状的影响。
We present a novel approach to estimating functional relationships between forced expiratory volume in 1 second (FEV1) and asthma-related symptoms on a population-wide basis. We used asthma-related clinical trials that reported estimates of mean lung function (measured as FEV1percent predicted) and symptoms (symptom score or percentage of symptom days or nighttime awakenings). Using average baseline values from each study in weighted linear regression analyses, we found a negative association between lung function and symptom score (P < 0.001) and the percentage of nighttime awakenings (P = 0.18), but no association between lung function and symptom days. We also found consistent relationships between the mean changes in lung function and symptoms at follow-up within the studies. Functional relationships between FEV1percent predicted and asthma-related symptoms can be useful for inferring the effect on the symptoms of a population associated with overall improvements in lung function.