Prevalence of hepatitis B and C virus infections in the general Chinese population. Results from a nationwide cross-sectional seroepidemiologic study of hepatitis A, B, C, D, and E virus infections in China, 1992
Prevalence of hepatitis B and C virus infections in the general Chinese population. Results from a nationwide cross-sectional seroepidemiologic study of hepatitis A, B, C, D, and E virus infections in China, 1992
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DOI：
10.1016/s0928-4346(96)82012-3
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发表时间：
1996-05-01
期刊：
影响因子：
--
通讯作者：
Qi, XQ
中科院分区：
文献类型：
--
作者：
Xia, GL;Liu, CB;Qi, XQ
病毒性肝炎是我国的一个重大公共卫生问题，严重影响人民健康。为了解中国人群肝炎病毒感染的分布情况，为制定和评价病毒性肝炎的预防措施和公共卫生措施提供依据，于1992年在中国进行了全国性肝炎病毒感染的横断面血清流行病学研究。采用两阶段整群抽样方法，在全国30个省、自治区、直辖市的145个国家疾病监测点共抽取1-59岁人群68 000人。使用市售试剂测定血清标本。检测的标志物包括乙型肝炎表面抗原、抗乙型肝炎病毒c、抗乙型肝炎表面抗原、乙型肝炎e抗原和抗丙型肝炎病毒。在中国30个省、自治区、直辖市共调查61702人，HBsAg携带率为9.75%（4.49-17.85%）。1-4岁年龄组的比率与总比率一样高。10-14岁和30-34岁年龄组的比例较高，50-59岁年龄组的比例较低。我国不同地区、不同性别HBsAg携带率差异较大，中南地区HBsAg携带率最高，北方地区HBsAg携带率较低。HBV感染、抗-HBc和抗-HBs的总检出率分别为57.63%、49.81%和27.42%，随年龄增长而显著增加，从1-4岁组的38.47%、30.08%和15.75%分别增至50-59岁组的70.69%、61.77%和32.42%。HBsAg携带者中HBeAg总检出率为31.94%。在中国30个省份的66975名受试者中，抗-HCV的总体患病率为3.2%（范围为0.9-5.1%），随着年龄的增长而显著增加，从1-4岁年龄组的2.08%增加到50-59岁年龄组的3.96%。抗-HCV阳性率在性别和居住地区之间无差异。不同地区、不同行政区划人群抗-HCV阳性率差异有统计学意义，东北地区抗-HCV阳性率最高。这些结果表明，B和C型肝炎在中国是高流行的。根据年龄、性别和地区分布特点，我们认为这两种病毒在中国的主要传播方式可能不同。
Viral hepatitis is a major public health problem in China and has a substantial impact on the health of people. To understand the distribution of hepatitis virus infection in the general Chinese population and provide basis for developing and evaluating preventive procedures and public health practices on viral hepatitis control, a nationwide cross-sectional seroepidemiologic study of hepatitis virus infections was carried out in China, 1992. Using two-stage cluster sampling, a total of 68 000 subjects were studied, aged 1-59 years, covering all 145 national disease surveillance points of 30 provinces, autonomous regions and municipalities. Serum specimens were assayed using commercial reagents. Tested markers include HBsAg, anti-HBc, anti-HBs, HBeAg and anti-HCV. The overall prevalence of HBsAg carrier was 9.75% of 61 702 subjects studied (range 4.49-17.85%) in 30 provinces of China. The rate in the 1-4 age group was as high as the overall rate. There were higher rates in both the 10-14 and 30-34 age groups, and lower in the 50-59 age group. There were considerable variations in the prevalence of HBsAg carrier in different regions and sex in China, with the highest rate being in middle south and lower rates in north China. The overall prevalence of HBV infection, anti-HBc and anti-HBs were 57.63%, 49.81% and 27.42%, respectively; increasing significantly with age from 38.47%, 30.08% and 15.75% in the 1-4 age group to 70.69%, 61.77% and 32.42% in 50-59 age group, respectively. The overall prevalence of HBeAg was 31.94%, among HBsAg carriers. The overall prevalence of anti-HCV was 3.2% of 66 975 subjects studied (range 0.9-5.1%) among 30 provinces of China, increasing significantly with age from 2.08% in the 1-4 age group to 3.96% in the 50-59 age group. There was no difference in the rate of anti-HCV by sex and living district. However, there were significant difference in rates of anti-HCV in different geographical areas and administrative divisions in China, with the highest rates being in the northeast of China. These results indicate that hepatitis B and C are hyperendemic in China. According to characteristics of distribution among age, sex and regions, we suggest that the main modes of transmission of the two virus are probably different in China.