Synthesis of Ureidomuraymycidine Derivatives for Structure-Activity Relationship Studies of Muraymycins
Synthesis of Ureidomuraymycidine Derivatives for Structure-Activity Relationship Studies of Muraymycins
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DOI：
10.1021/jo300205b
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发表时间：
2012-04-20
影响因子：
3.6
通讯作者：
Kurosu, Michio
中科院分区：
文献类型：
--
作者：
Aleiwi, Bilal A.;Schneider, Christopher M.;Kurosu, Michio
胞霉素的主要成分之一是6元环胍(2S,3S)-胞霉素（或表旋霉素）。为了使多聚霉素的寡肽部分结构多样化，以便深入研究结构-活性关系，我们利用内酯4a合成了高立体选择性的脲多聚霉素衍生物。
One of the key constituents of the muraymycins is the 6-membered cyclic guanidine, (2S,3S)-muraymycidine (or epi-capreomycidine). In order to diversify the structure of the oligopeptide moiety of the muraymycins for thorough structure activity relationship studies, we have developed a highly stereoselective synthesis of ureidomuraymycidine derivatives with the lactone 4a.